Shared genetic determinants (p≤1.0×10−3) between osteoarthritis and height
| SNP | Chromosome | Allele | Osteoarthritis p value | Osteoarthritis OR | 95% CI | Height p value | Height OR | 95% CI | Nearest gene |
|---|---|---|---|---|---|---|---|---|---|
| rs2744718 | 1 | T | 8.9×10−5 | 1.20 | 1.10 to 1.31 | 3.5×10−5 | 0.98 | 0.97 to 0.99 | WNT4 |
| rs6670486 | 1 | T | 9.6×10−5 | 1.16 | 1.07 to 1.24 | 6.5×10−7 | 0.98 | 0.98 to 0.98 | COL11A1 |
| rs4833772 | 4 | G | 2.5×10−4 | 1.12 | 1.05 to 1.19 | 1.3×10−5 | 1.02 | 1.01 to 1.02 | TMEM155 |
| rs572004 | 6 | G | 2.4×10−4 | 1.14 | 1.06 to 1.22 | 7.5×10−5 | 0.98 | 0.97 to 0.99 | EYA4 |
| rs3822856 | 6 | A | 9.2×10−4 | 1.12 | 1.05 to 1.19 | 6.5×10−4 | 0.99 | 0.98 to 0.99 | NT5DC1 |
| rs1635853 | 7 | T | 2.0×10−5 | 1.15 | 1.08 to 1.22 | 8.8×10−21 | 1.04 | 1.03 to 1.04 | JAZF1 |
| rs10094727 | 8 | A | 3.7×10−4 | 1.23 | 1.10 to 1.39 | 6.0×10−5 | 0.97 | 0.06 to 0.98 | MSR1 |
| rs9657371 | 8 | A | 1.3×10−4 | 1.13 | 1.06 to 1.21 | 2.7×10−5 | 0.98 | 0.97 to 0.99 | CSMD1 |
| rs11991139 | 8 | C | 6.2×10−5 | 1.14 | 1.06 to 1.22 | 4.3×10−4 | 0.98 | 0.98 to 0.99 | BLK |
| rs3808880 | 9 | G | 7.5×10−4 | 1.13 | 1.05 to 1.21 | 6.8×10−4 | 1.01 | 1.01 to 1.02 | ROD1 |
| rs11198893 | 10 | A | 3.8×10−4 | 1.22 | 1.09 to 1.36 | 5.7×10−4 | 1.02 | 1.01 to 1.03 | GRK5 |
| rs7932272 | 11 | A | 1.1×10−4 | 1.30 | 1.12 to 1.52 | 2.4×10−7 | 1.04 | 1.03 to 1.06 | PACS1 |
| rs7297051 | 12 | T | 3.3×10−4 | 1.14 | 1.05 to 1.23 | 6.0×10−5 | 1.02 | 1.01 to 1.03 | PTHLH |
| rs10506474 | 12 | C | 5.2×10−4 | 1.15 | 1.06 to 1.27 | 4.4×10−5 | 0.99 | 0.97 to 0.99 | HMGA2 |
| rs4793927 | 17 | C | 1.4×10−4 | 1.14 | 1.06 to 1.22 | 3.0×10−6 | 1.02 | 1.01 to 1.03 | HOXB3 |
| rs2864419 | 19 | G | 8.4×10−5 | 1.14 | 1.07 to 1.21 | 1.1×10−12 | 1.03 | 1.02 to 1.04 | DOT1L |
| rs8105885 | 19 | T | 7.9×10−4 | 1.20 | 1.08 to 1.37 | 4.3×10−4 | 0.98 | 0.96 to 0.98 | ZNF98 |
SNP, single nucleotide polymorphism.