Descriptive statistics of knee OA cases in the study cohorts
| Study cohort | Goal | HCS | Nottingham |
|---|---|---|---|
| Patients collected from | Secondary care | Community | Secondary care |
| Number of knee OA cases | 1879 | 557 | 1038 |
| F% | 48.6% | 45.6% | 57.0% |
| Age (SD) | 68.23 (7.22) | 65.62 (2.62) | 70.02 (9.47) |
| Body mass index (SD) | 30.49 (5.38) | 27.82 (4.48) | 29.97 (5.74) |
| Patellofemoral K/L grade | |||
| <2 | 19.5% | 2.9% | 25.0% |
| 2 | 34.6% | 43.1% | 46.8% |
| 3 | 34.2% | 24.1% | 19.8% |
| 4 | 11.7% | 30.0% | 8.4% |
| Tibiofemoral K/L grade | |||
| <2 | 14.7% | 73.2% | 2.2% |
| 2 | 16.8% | 18.9% | 9.3% |
| 3 | 46.2% | 7.2% | 61.5% |
| 4 | 22.2% | 0.7% | 27.0% |
| Risk allele frequencies | |||
| rs143383 (T) | 65.81% | 61.67% | 64.40% |
| rs11842874 (A) | 93.82% | 92.84% | 94.61% |
| rs4730250 (T) | 15.63% | 15.57% | 17.51% |
GOAL, Genetics of Osteoarthritis and Lifestyle study; HCS, Hertfordshire Cohort Study; Nottingham, Nottingham Case-Control Study.