Number | MAF | Genotype counts | Genotype frequencies | HWE | p Value | 95% CI | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Marker | Chr | Gene | Case | Controls | Cases | Controls | Cases | Controls | Cases | Controls | Cases | Controls | Trend | OR | Lower | Upper |
rs2476601 | 1 | PTPN22 | 982 | 5568 | 0.11 | 0.10 | 15/185/782 | 45/991/4532 | 1.5/18.8/79.6 | 0.8/17.8/81.4 | 0.323 | 0.284 | 0.08863 | 1.14 | 0.98 | 1.34 |
rs11586238 | 1 | CD2 | 980 | 5750 | 0.24 | 0.23 | 65/342/573 | 330/2036/3384 | 6.6/34.9/58.5 | 5.7/35.4/58.9 | 0.162 | 0.304 | 0.5419 | 1.04 | 0.93 | 1.16 |
rs7543174 | 1 | IL6R | 972 | 5560 | 0.17 | 0.18 | 25/277/670 | 174/1656/3730 | 2.6/28.5/68.9 | 3.1/29.8/67.1 | 0.647 | 0.586 | 0.2 | 0.92 | 0.81 | 1.05 |
rs13031237 | 2 | REL | 972 | 5560 | 0.34 | 0.38 | 115/431/426 | 781/2617/2162 | 11.8/44.3/43.8 | 14.0/47.1/38.9 | 0.721 | 0.819 | 0.002569 | 0.86 | 0.77 | 0.95 |
rs13017599 | 2 | REL | 971 | 5553 | 0.33 | 0.38 | 107/436/428 | 781/2612/2160 | 11.0/44.9/44.1 | 14.1/47.0/38.9 | 0.829 | 0.864 | 0.0005242 | 0.84 | 0.75 | 0.93 |
rs1160542 | 2 | AFF3 | 981 | 5568 | 0.47 | 0.46 | 229/472/280 | 1157/2798/1613 | 23.3/48.1/28.5 | 20.8/50.3/29.0 | 0.277 | 0.388 | 0.2194 | 1.06 | 0.96 | 1.17 |
rs10865035 | 2 | AFF3 | 981 | 3296 | 0.48 | 0.46 | 237/472/272 | 667/1678/951 | 24.2/48.1/27.7 | 20.2/50.9/28.9 | 0.250 | 0.150 | 0.04775 | 1.11 | 1.00 | 1.22 |
rs10181656 | 2 | STAT4 | 980 | 3832 | 0.25 | 0.22 | 67/359/554 | 180/1327/2325 | 6.8/36.6/56.5 | 4.7/34.6/60.7 | 0.397 | 0.638 | 0.003032 | 1.19 | 1.06 | 1.34 |
rs1980422 | 2 | CD28 | 975 | 5747 | 0.25 | 0.23 | 54/372/549 | 273/2051/3423 | 5.5/38.2/56.3 | 4.8/35.7/59.6 | 0.437 | 0.131 | 0.0471 | 1.12 | 1.00 | 1.25 |
rs231775 | 2 | CTLA4 | 971 | 5568 | 0.39 | 0.39 | 144/468/359 | 852/2675/2041 | 14.8/48.2/37.0 | 15.3/48.0/36.7 | 0.686 | 0.633 | 0.7419 | 0.98 | 0.89 | 1.09 |
rs3087243 | 2 | CTLA4 | 978 | 5748 | 0.43 | 0.44 | 162/511/305 | 1126/2850/1772 | 16.6/52.2/31.2 | 19.6/49.6/30.8 | 0.037 | 0.749 | 0.1609 | 0.93 | 0.85 | 1.03 |
rs4535211 | 3 | PLCL2 | 975 | 5745 | 0.53 | 0.49 | 262/503/210 | 1376/2857/1512 | 26.9/51.6/21.5 | 24.0/49.7/26.3 | 0.304 | 0.712 | 0.001663 | 1.17 | 1.06 | 1.28 |
rs13315591 | 3 | FAM107A | 973 | 5740 | 0.09 | 0.08 | 6/164/803 | 37/878/4825 | 0.6/16.9/82.5 | 0.6/15.3/84.1 | 0.560 | 0.729 | 0.2671 | 1.10 | 0.93 | 1.30 |
rs874040 | 4 | RBPJ | 972 | 5704 | 0.32 | 0.30 | 100/423/449 | 511/2404/2789 | 10.3/43.5/46.2 | 9.0/42.1/48.9 | 1.000 | 0.850 | 0.0736 | 1.10 | 0.99 | 1.22 |
rs2069778 | 4 | IL2 | 960 | 3699 | 0.16 | 0.18 | 19/269/672 | 124/1086/2489 | 2.0/28.0/70.0 | 3.4/29.4/67.3 | 0.229 | 0.697 | 0.03611 | 0.87 | 0.76 | 0.99 |
rs6822844 | 4 | IL21 | 958 | 5549 | 0.16 | 0.17 | 20/264/674 | 155/1631/3763 | 2.1/27.6/70.4 | 2.8/29.4/67.8 | 0.396 | 0.178 | 0.07937 | 0.89 | 0.78 | 1.02 |
rs10040327 | 5 | ANKRD55 | 970 | 5737 | 0.10 | 0.12 | 7/186/777 | 102/1139/4496 | 0.7/19.2/80.1 | 1.8/19.9/78.4 | 0.300 | 0.004 | 0.07912 | 0.87 | 0.74 | 1.01 |
rs26232 | 5 | C5orf30 | 972 | 5558 | 0.32 | 0.33 | 95/430/447 | 575/2511/2472 | 9.8/44.2/46.0 | 10.3/45.2/44.5 | 0.606 | 0.095 | 0.3614 | 0.95 | 0.86 | 1.06 |
rs548234 | 6 | PRDM1 | 980 | 5751 | 0.31 | 0.33 | 92/423/465 | 604/2599/2548 | 9.4/43.2/47.4 | 10.5/45.2/44.3 | 0.823 | 0.129 | 0.06098 | 0.91 | 0.82 | 1.01 |
rs13207033 | 6 | TNFAIP3 | 960 | 5723 | 0.26 | 0.28 | 63/371/526 | 451/2260/3012 | 6.6/38.6/54.8 | 7.9/39.5/52.6 | 0.867 | 0.355 | 0.1154 | 0.92 | 0.82 | 1.02 |
rs6920220 | 6 | TNFAIP3 | 959 | 5723 | 0.21 | 0.22 | 48/312/599 | 289/1968/3466 | 5.0/32.5/62.5 | 5.0/34.4/60.6 | 0.385 | 0.647 | 0.3449 | 0.94 | 0.84 | 1.06 |
rs5029937 | 6 | TNFAIP3 | 956 | 3447 | 0.03 | 0.03 | 2/52/902 | 5/229/3213 | 0.2/5.4/94.4 | 0.1/6.6/93.2 | 0.191 | 0.607 | 0.2508 | 0.84 | 0.63 | 1.13 |
rs394581 | 6 | TAGAP | 978 | 2988 | 0.32 | 0.31 | 102/417/459 | 298/1271/1419 | 10.4/42.6/46.9 | 10.0/42.5/47.5 | 0.606 | 0.580 | 0.6767 | 1.02 | 0.92 | 1.14 |
rs3093023 | 6 | CCR6 | 968 | 5735 | 0.42 | 0.43 | 146/523/299 | 1099/2778/1858 | 15.1/54.0/30.9 | 19.2/48.4/32.4 | 0.001 | 0.295 | 0.29 | 0.95 | 0.86 | 1.05 |
rs42041 | 7 | CDK6 | 982 | 5747 | 0.26 | 0.25 | 62/387/533 | 342/2144/3261 | 6.3/39.4/54.3 | 6.0/37.3/56.7 | 0.507 | 0.696 | 0.1781 | 1.08 | 0.97 | 1.20 |
rs10488631 | 7 | IRF5 | 973 | 5559 | 0.11 | 0.11 | 14/194/765 | 59/1085/4415 | 1.4/19.9/78.6 | 1.1/19.5/79.4 | 0.635 | 0.444 | 0.4412 | 1.06 | 0.91 | 1.24 |
rs2736340 | 8 | BLK | 971 | 5741 | 0.24 | 0.25 | 50/373/548 | 330/2158/3253 | 5.1/38.4/56.4 | 5.7/37.6/56.7 | 0.222 | 0.269 | 0.8585 | 0.99 | 0.89 | 1.11 |
rs2812378 | 9 | CCL21 | 960 | 5723 | 0.37 | 0.34 | 138/433/389 | 643/2615/2465 | 14.4/45.1/40.5 | 11.2/45.7/43.1 | 0.332 | 0.206 | 0.01475 | 1.13 | 1.02 | 1.25 |
rs951005 | 9 | CCL21 | 973 | 5558 | 0.16 | 0.15 | 27/249/697 | 111/1406/4041 | 2.8/25.6/71.6 | 2.0/25.3/72.7 | 0.394 | 0.421 | 0.2876 | 1.08 | 0.94 | 1.23 |
rs10760130 | 9 | TRAF1/C5 | 959 | 5549 | 0.44 | 0.44 | 189/466/304 | 1089/2680/1780 | 19.7/48.6/31.7 | 19.6/48.3/32.1 | 0.694 | 0.164 | 0.8523 | 1.01 | 0.92 | 1.11 |
rs2900180 | 9 | TRAF1/C5 | 982 | 5570 | 0.35 | 0.35 | 120/445/417 | 706/2479/2385 | 12.2/45.3/42.5 | 12.7/44.5/42.8 | 0.944 | 0.118 | 0.9659 | 1.00 | 0.90 | 1.10 |
rs706778 | 10 | IL2RA | 965 | 5740 | 0.42 | 0.40 | 193/432/340 | 936/2737/2067 | 20.0/44.8/35.2 | 16.3/47.7/36.0 | 0.010 | 0.564 | 0.06669 | 1.10 | 0.99 | 1.21 |
rs2104286 | 10 | IL2RA | 980 | 5743 | 0.27 | 0.28 | 73/390/517 | 462/2297/2984 | 7.4/39.8/52.8 | 8.0/40.0/52.0 | 1.000 | 0.493 | 0.5272 | 0.97 | 0.87 | 1.08 |
rs11594656 | 10 | IL2RA | 976 | 5749 | 0.23 | 0.24 | 66/320/590 | 342/2087/3320 | 6.8/32.8/60.5 | 5.9/36.3/57.7 | 0.015 | 0.564 | 0.3705 | 0.95 | 0.85 | 1.06 |
rs4750316 | 10 | PRKCQ | 982 | 5749 | 0.17 | 0.19 | 24/290/668 | 222/1745/3782 | 2.4/29.5/68.0 | 3.9/30.4/65.8 | 0.313 | 0.248 | 0.0562 | 0.88 | 0.78 | 1.00 |
rs540386 | 11 | TRAF6 | 973 | 5736 | 0.14 | 0.13 | 24/215/734 | 101/1327/4308 | 2.5/22.1/75.4 | 1.8/23.1/75.1 | 0.098 | 0.955 | 0.8234 | 1.02 | 0.88 | 1.17 |
rs1678542 | 12 | KIF5A | 958 | 5723 | 0.42 | 0.39 | 184/434/340 | 896/2675/2152 | 19.2/45.3/35.5 | 15.7/46.7/37.6 | 0.034 | 0.182 | 0.02048 | 1.13 | 1.02 | 1.24 |
rs3184504 | 12 | SH2B3 | 963 | 5555 | 0.50 | 0.49 | 248/467/248 | 1298/2819/1438 | 25.8/48.5/25.8 | 23.4/50.7/25.9 | 0.367 | 0.248 | 0.305 | 1.05 | 0.95 | 1.16 |
rs7234029 | 18 | PTNP2 | 972 | 5731 | 0.17 | 0.16 | 24/273/675 | 128/1536/4067 | 2.5/28.1/69.4 | 2.2/26.8/71.0 | 0.642 | 0.249 | 0.3219 | 1.07 | 0.94 | 1.22 |
rs4810485 | 20 | CD40 | 960 | 5723 | 0.25 | 0.24 | 66/354/540 | 332/2088/3303 | 6.9/36.9/56.2 | 5.8/36.5/57.7 | 0.443 | 0.942 | 0.2308 | 1.07 | 0.96 | 1.20 |
rs11203203 | 21 | UBASH3A | 966 | 5731 | 0.35 | 0.37 | 119/440/407 | 786/2696/2249 | 12.3/45.5/42.1 | 13.7/47.0/39.2 | 1.000 | 0.651 | 0.07026 | 0.91 | 0.82 | 1.01 |
rs3218258 | 22 | IL2RB | 979 | 5569 | 0.27 | 0.26 | 76/379/524 | 381/2161/3027 | 7.8/38.7/53.5 | 6.8/38.8/54.4 | 0.518 | 0.890 | 0.4175 | 1.05 | 0.94 | 1.17 |
rs743777 | 22 | IL2RB | 960 | 5723 | 0.33 | 0.31 | 100/431/429 | 549/2450/2724 | 10.4/44.9/44.7 | 9.6/42.8/47.6 | 0.609 | 0.975 | 0.102 | 1.09 | 0.98 | 1.21 |
Chr, chromosome; HWE, Hy–Weinberg equilibrium; MAF, minor allele frequency; SNP, single nucleotide polymorphism.