Subphenotype analysis of the seven SNPs in UK dataset (control data are from the WTCCC2 only—see supplementary table 1, available online only)
| SNP | Seronegative | Type I psoriasis | Type II psoriasis | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| rs | Locus | 11 | 12 | 22 | Trend p value | OR (CI) | 11 | 12 | 22 | Trend p value | OR (CI) | 11 | 12 | 22 | Trend p value | OR (CI) |
| rs2066808 | 12q13 | 0 | 26 | 275 | 0.01 | 0.60 (0.40 to 0.89) | 0 | 46 | 431 | 0.01 | 0.67 (0.49 to 0.91) | 1 | 8 | 154 | 0.01 | 0.42 (0.22 to 0.79) |
| rs17728338 | 5q33 | 1 | 45 | 256 | 0.02 | 1.45 (1.06 to 1.98) | 2 | 77 | 399 | 1.4×10−4 | 1.59 (1.25 to 2.03) | 1 | 18 | 144 | 0.62 | 1.12 (0.71 to 1.78) |
| rs495337 | 20q13 | 52 | 159 | 129 | 0.06 | 0.85 (0.72 to 1.01) | 73 | 253 | 196 | 0.01 | 0.84 (0.73 to 0.96) | 21 | 90 | 65 | 0.07 | 0.81 (0.65 to 1.02) |
| rs610604 | 6q23 | 36 | 130 | 136 | 0.35 | 1.09 (0.91 to 1.29) | 50 | 237 | 191 | 0.02 | 1.18 (1.03 to 1.35) | 20 | 81 | 62 | 0.04 | 1.28 (1.02 to 1.61) |
| rs1076160 | 9q34 | 66 | 155 | 80 | 0.30 | 0.92 (0.78 to 1.08) | 100 | 247 | 131 | 0.07 | 0.88 (0.77 to 1.01) | 36 | 86 | 40 | 0.70 | 0.96 (0.77 to 1.20) |
| rs12983316 | 19p13 | 6 | 82 | 210 | 0.82 | 0.97 (0.78 to 1.22) | 10 | 123 | 341 | 0.40 | 0.92 (0.77 to 1.11) | 3 | 50 | 110 | 0.59 | 1.08 (0.81 to 1.45) |
| rs397211 | 2q13 | 31 | 120 | 149 | 0.8 | 0.98 (0.82 to 1.17) | 47 | 190 | 234 | 0.66 | 0.97 (0.84 to 1.12) | 17 | 60 | 86 | 0.44 | 0.91 (0.71 to 1.16) |
SNP, single-nucleotide polymorphism.