| 30 mg | 75 mg | 150 mg | All | |
|---|---|---|---|---|
| Change on placebo 0–6 mo | 2.55 | 2.01 | 5.79 | 3.43 |
| Change on anakinra 6–12 mo | 1.10 | 0.88 | 1.99 | 1.31 |
| Difference placebo - > anakinra | -1.46 (n = 19) p = 0.008 | -1.13 (n = 20) p = 0.010 | -3.81 (n = 19) p = 0.002 | -2.11 (n = 58) p < 0.001 |
| Change on anakinra 0–6 mo | 1.74 | 1.95 | 1.78 | 1.82 |
| Change on anakinra 6–12 mo | 1.61 | 0.95 | 0.85 | 1.18 |
| Difference anakinra - > anakinra | -0.13 (n = 68) p = 0.282 | -1.00 (n = 61) p = 0.006 | -0.93 (n = 49) p = 0.008 | -0.65 (n = 178) p < 0.001 |
p values are results of Wilcoxon signed rank test.