Predictors of observed active digital ulcers (DUs) and of reported recent DUs (since previous visit) at prospective visits
| Covariate (at baseline) | Active DUs | Reported recent DUs | ||||||
|---|---|---|---|---|---|---|---|---|
| HR (95% CI) Analysis adjusted only for age and gender | p Value | HR (95% CI) Analysis adjusted for age, gender and all listed covariates | p Value | HR (95% CI) Analysis adjusted only for age and gender | p Value | HR (95% CI) Analysis adjusted for age, gender and all listed covariates | p Value | |
| HDU | 2.60 (2.19 to 3.08) | <0.001 | 2.41 (1.91 to 3.03) | <0.001 | 3.59 (3.23 to 3.99) | <0.001 | 3.23 (2.78 to 3.74) | <0.001 |
| Anti-topo I antibodies | 2.09 (1.76 to 2.48) | <0.001 | 1.78 (1.39 to 2.28) | <0.001 | 1.81 (1.62 to 2.01) | <0.001 | 1.41 (1.20 to 1.66) | <0.001 |
| Joint contractures | 2.15 (1.81 to 2.56) | <0.001 | 1.53 (1.20 to 1.94) | <0.001 | 2.04 (1.83 to 2.27) | <0.001 | 1.38 (1.18 to 1.61) | <0.001 |
| Elevated US-PAPs | 1.52 (1.22 to 1.86) | <0.001 | 1.37 (1.05 to 1.81) | 0.023 | 1.49 (1.30 to 1.70) | <0.001 | 1.41 (1.17 to 1.69) | <0.001 |
| DLCO<80% predicted | 1.61 (1.26 to 2.06) | <0.001 | 1.29 (1.00 to 1.66) | 0.055 | 1.66 (1.48 to 1.85) | <0.001 | 1.08 (0.92 to 1.27) | 0.349 |
| Diffuse cutaneous subset | 1.65 (1.38 to 1.97) | <0.001 | 1.15 (0.89 to 1.49) | 0.282 | 1.61 (1.26 to 2.06) | <0.001 | 1.22 (1.02 to 1.44) | 0.024 |
Bold typeface highlights the baseline covariate of interest, HDU.
Cox proportional hazards analysis adjusted only for age and gender (left column for each outcome) and for age, gender and all clinically important covariates (right column for each outcome).
DLCO, lung CO diffusion; Elevated US-PAPs, a systolic pulmonary arterial pressure >40 mm Hg as measured by power Doppler heart ultrasound examinationl; HDU, history of digital ulcers at baseline.