Table 2

Rheumatoid arthritis (RA) activity/severity measures and their association with risk of cardiovascular disease

RA activity/severity measureVariablesHR* (95% CI)p Value
Flare/intermediate/remissionDaily flare0.96 (0.46 to 1.99)0.91
Daily intermediate activity1.30 (0.77 to 2.20)
Daily remission1 (reference)
 Years in flare1.01 (0.89 to 1.44)0.40†
Years in intermediate activity0.92 (0.81 to 1.04)
Years in remission1 (reference)
Acute flare/intermediate/remissionDaily acute flare1.70 (0.62 to 4.64)0.30
Daily intermediate activity1.39 (0.80 to 2.41)
Daily remission1 (reference)
 Years in acute flare1.87 (1.04 to 3.35)0.056†
Years in intermediate activity0.95 (0.84 to 1.08)
Years in remission1 (reference)
CIRASDaily CIRAS1.27 (1.11 to 1.46)0.0005
Daily cumulative average CIRAS1.38 (1.12 to 1.70)0.002
 Years in low CIRAS tertile1 (reference)0.006†
Years in medium CIRAS tertile1.08 (0.98 to 1.20)
Years in high CIRAS tertile1.18 (1.06 to 1.31)
RARBIS with medicationsDaily RARBIS with medications1.10 (1.01 to 1.21)0.04
Daily cumulative average RARBIS1.16 (1.03 to 1.30)0.01
 Years in low RARBIS tertile1 (reference)0.18†
Years in medium RARBIS tertile0.98 (0.90 to 1.07)
Years in high RARBIS tertile1.06 (0.99 to 1.14)
RARBIS without medicationsDaily RARBIS without medications1.15 (1.04 to 1.27)0.006
Daily cumulative average RARBIS1.17 (1.04 to 1.33)0.01
 Years in low RARBIS tertile1 (reference)0.052†
Years in medium RARBIS tertile1.11 (1.00 to 1.24)
Years in high RARBIS tertile1.07 (1.00 to 1.14)
  • *Adjusted for age, sex, year of RA, cardiovascular risk factors (hypertension, diabetes mellitus, dyslipidaemia, smoking status) and antirheumatic medications (methotrexate, hydroxychloroquine, other disease-modifying antirheumatic drugs, biologics and corticosteroids).

  • †Generalised test of a difference between the tertiles.

  • CIRAS, Claims-based Index of Rheumatoid Arthritis Severity; RARBIS, Rheumatoid Arthritis medical Records-Based Index of Severity.