Table 2

Tentative cut-off of disease activity levels with ESSDAI and PASS with ESSPRI

EULAR cohortASSESS cohort
At baselineAt 6 months
ESSDAI cut-off
Low vs moderate
 ROC curve analysis955
  AUC0.8260.8090.709
 Sensitivity/specificity78.6%%/69.7%70.3%/76.6%72.3%/58.3%
 Anchoring method
  75th centile of the distribution in MDA group9 [7 to 11]6 [5 to 8]6 [5 to 8]
Moderate vs high
 ROC curve141514
  AUC0.9510.8660.823
 Sensitivity/specificity85.0%/100%89.3%/75.0%93.3%/66.7%
 In non-MDA group
  75th centile of the distribution17 [15 to 20]16 [12 to 19]12.5 [10 to 15]
ESSPRI: PASS estimating method
 Anchoring method
  75th centile of the distribution in the PASS group6.33 [5.67 to 6.67]6 [5.67 to 7.00]
 ROC curve analysis6.335.33
  AUCAUC=0.750AUC=0.704
 Sensitivity/specificity71.5%/66.3%64.7%/66.7%
  • ASSESS, Assessment of Systemic Signs and Evolution of SS; AUC, area under the curve; EULAR, European League Against Rheumatism; ESSDAI, EULAR Sjögren’s syndrome disease activity index; ESSPRI, EULAR Sjögren's syndrome patient-reported index; MDA, minimal disease activity; PASS, patient-acceptable symptom state; ROC, receiver operating characteristic.