Table 4

Baseline MRI findings as predictors for radiographic progression according to the Kellgren–Lawrence scale in the same joint

Presence of MRI featuresOR (95% CI) of radiographic progression (KLG)
(in joints with baseline KLG=0–3)
n (%)Crude associationsAdjusted associations*
Synovitis
 Grade 1196/435 (45.1)2.02 (1.25 to 3.25); p=0.0042.65 (1.55 to 4.55); p<0.001
 Grades 2 and 3†97/435 (22.3)3.07 (1.63 to 5.76); p<0.0012.88 (1.41 to 5.89); p=0.004
Flexor tenosynovitis79/424 (18.6)1.04 (0.66 to 1.66); p=0.860.46 (0.23 to 0.93); p=0.03
Focal erosions209/489 (42.7)0.92 (0.66 to 1.28); p=0.630.94 (0.67 to 1.32); p=0.72
Subchondral bone attrition39/490 (8.0)0.92 (0.46 to 1.87); p=0.830.93 (0.42 to 2.05); p=0.86
Cysts20/489 (4.1)1.92 (0.88 to 4.17); p=0.101.72 (0.72 to 4.09); p=0.22
Osteophytes (grades 2 and 3)‡98/492 (19.9)0.81 (0.47 to 1.41); p=0.460.90 (0.47 to 1.72); p=0.75
Joint space narrowing
 Grade 1181/492 (36.8)1.66 (0.96 to 2.89); p=0.071.18 (0.60 to 2.29); p=0.63
 Grade 2117/492 (23.8)2.37 (1.37 to 4.10); p=0.0021.96 (1.01 to 3.81); p=0.05
 Grade 317/492 (3.4)4.06 (1.56 to 10.54); p=0.0042.26 (0.85 to 5.99); p=0.10
Bone marrow lesions50/497 (10.1)2.06 (1.14 to 3.74); p=0.022.00 (1.08 to 3.71); p=0.03
Malalignment22/493 (4.5)0.88 (0.35 to 2.17); p=0.770.64 (0.19 to 2.18); p=0.47
Collateral ligament discontinuity245/492 (49.8)0.96 (0.67 to 1.41); p=0.870.99 (0.67 to 1.47); p=0.10
  • Generalised Estimating Equations with separate models for each MRI feature. Statistically significant associations are shown in italics.

  • *Adjusted for age, sex, BMI and follow-up time.

  • †Few joints with synovitis grade 3 (n=8).

  • ‡Osteophyte grades 2 and 3 versus grade 0 (n=74) and grade 1 (n=320) as reference.

  • BMI, Body Mass Index; KLG, Kellgren–Lawrence grade.