Table 1

Genes with significantly differentially methylated probes found at GWAS at-risk loci

GeneIDProbeID on 450 K BeadChipsCHRChromosome positionDifference in median of DNA methylation in patients vs controls (%)
Panel (A): Overlap with GWAS at-risk loci in American and French patients with pSS
HLA-DRAcg003831366324102477.25
HLA-DRAcg055007836324108739.00
HLA-DRAcg130229936324098569.85
HLA-DRAcg2293746263241118512.00
HLA-DRAcg257645706324072899.37
HLA-DRAcg266841316324103658.41
HLA-DRAcg1760618363240941313.11
HLA-DRAcg237326296324093868.80
HLA-DQB1cg2459391863263315711.44
HLA-DQA1cg102170526326071748.57
IRF5cg04864179712857996413.23
IRF5cg12816198712857759314.23
CXCR5cg04537602111187638599.49
CXCR5cg13298528111187638639.03
CXCR5cg24342283111187586038.18
CXCR5cg19791714111187639019.66
CXCR5cg01943632111187643378.54
CXCR5cg06583259111187589927.31
BLKcg044416678113566037.26
BLKcg16861076811421594−7.14
PRDM1cg1714317961065468249.44
ITSN2cg1172446122455319214.89
ITSN2cg066526322245840817.83
Panel (B): Overlap with GWAS at-risk loci in Chinese Han patients with pSS
GTF2Icg2198353177407531718.21
HLA-DQA1cg102170526326071748.57
HLA-DPB1cg2115196363304322011.69
HLA-DPB1cg1013684163304658210.43
HLA-DPB1cg2375036563304307210.24
COL11A2cg133904806331385037.64
  • GWAS, genome-wide association study; pSS, primary Sjögren's syndrome.