Table 2

Synovial tissue volume and pain: baseline and follow-up visits

Baseline visitFollow-up visitDifference*Difference; non-responders†Difference; responders†
VariableMean (SD)Mean (SD)Mean (95% CI)p ValueMean (95% CI)Mean (95% CI)
Synovitis volume (mm3)9935 (6470)8864 (7802)−1071 (−1839 to −303)0.01−159 (−1553 to 1235)−1474 (−2401 to −548)
Synovial fluid volume (mm3)9872 (6852)9019 (7449)−853 (−1615 to −90)0.03−416 (−1797 to 964)−1045 (−1962 to −128)
KOOS pain subscale score‡ (0–100)45.6 (14.6)69.5 (19.8)23.9 (20.1 to 27.8)<0.0010.5 (−4.6 to 5.5)33.6 (30.4 to 36.8)
Pain on Nominated Activity VAS (0–10)6.53 (1.8)3.30 (2.7)−3.23 (−3.8 to −2.7)<0.001−0.7 (−1.5 to 0.2)−4.2 (−4.8 to −3.7)
  • *Within-person difference between baseline and follow-up visit.

  • †Responders are those who satisfied OARSI response criteria.

  • ‡Lower KOOS scores denote worse pain.

  • KOOS, Knee Injury and Osteoarthritis Outcome Score; VAS, Visual Analogue Scale.