Involvement of wrists, MCP and PIP joints
| Arthralgia | Rheumatoid arthritis | |||
|---|---|---|---|---|
| DAS28<2.6 | 2.6≥DAS28≤5.1 | DAS28>5.1 | ||
| No. of affected joints | ||||
| Tender joints (0–22)* | 1 (0–4) | 0 (0–1) | 2 (1–6) | 11 (5–13) |
| Swollen joints (0–22)* | 0 (0–0) | 0 (0–1) | 2 (1–4) | 6 (4–9) |
| GSUS>1 (0–22) | 0 (0–0) | 0 (0–0) | 1 (0–2) | 2 (1–5) |
| PDUS>0 (0–22) | 0 (0–0) | 0 (0–1) | 1 (0–4) | 2 (1–6) |
| US synovitis (GSUS>1 and/or PDUS>0) (0–22) | 0 (0–0) | 0 (0–1) | 1 (0–4) | 2 (1–6) |
| GSUS tenosynovitis (0–22) | 0 (0–0) | 0 (0–0) | 0 (0–0) | 0 (0–1) |
| PDUS tenosynovitis (0–22) | 0 (0–0) | 0 (0–1) | 0 (0–2) | 1 (0–5) |
| US inflammation (GSUS>1 and/or PDUS>0 and/or PDUS tenosynovitis) (0–22) | 0 (0–0) | 1 (0–2) | 2 (0–5) | 3 (2–7) |
| MRI joint count (synovitis>0) (0–6)† | – | 5 (3–5) | 4 (4–5) | – |
| MRI joint count (bone marrow oedema) (0–6)† | – | 1 (0–1) | 1 (0–1) | – |
| Severity of affected joints | ||||
| GSUS joint index (synovitis+tenosynovitis) (0–88) | 1 (0–1) | 2 (1–3) | 5 (2–7) | 9 (2–13) |
| PDUS joint index (synovitis+tenosynovitis) (0–88) | 0 (0–0) | 0 (0–2) | 2 (0–7) | 5 (2–12) |
| US joint index (GSUS synovitis+GSUS tenosynovitis+PDUS synovitis+PDUS tenosynovitis) (0–176) | 1 (0–1) | 2 (1–4) | 6 (3–1) | 13 (4–27) |
| RAMRIS synovitis (0–21) | – | 6 (4–8) | 6 (4–7) | – |
| RAMRIS bone marrow oedema (0–69) | – | 1 (0–2) | 1 (0–2) | – |
| RAMRIS (0–320) | – | 13 (8–18) | 19 (10–23) | – |
| OST joint index‡ | 4.13 (3.42–5.49) | 4.40 (3.48–5.10) | 5.90 (4.37–7.49) | 7.35 (4.27–10.28) |
Number of affected joints are presented as median (IQR).
*Average of the two physical examiners.
†MCP 1–5 and radiocarpal and intracarpal joints on right side only, MRI was performed in patients with DAS28<2.6 at recruitment; all patients with DAS28<2.6 at the study day and additionally 7 patients with 2.6≥DAS28≤5.1 (median (IQR) DAS28 of these 7 patients was 3.2 (2.9–3.3)).
‡Kruskal–Wallis one-way analysis of variance p=0.001.
DAS, Disease Activity Score; GSUS, grey-scale US; MCP, metacarpophalangeal; OST, optical spectral transmission; PDUS, power Doppler US; PIP, proximal interphalangeal; RAMRIS, Rheumatoid Arthritis MRI Scoring; US, ultrasonography.