Table 2

Associations of seven SNPs with gout types

Freq.ROL type vs controls*RUE type vs controls*Case–subtype heterogeneity test
SNP†GeneROL typeRUE typeOR (95% CI)p ValueOR (95% CI)p ValueOR (95% CI)p Value‡
rs3775948SLC2A90.620.701.38 (1.14 to 1.68)1.0×10−31.94 (1.63 to 2.31)1.0×10−130.66 (0.53 to 0.83)2.7×10−4
rs2188380MYL2-CUX20.840.851.45 (1.11 to 1.89)6.5×10−31.47 (1.16 to 1.86)1.2×10−30.92 (0.68 to 1.25)0.60
rs1260326§GCKR0.600.621.25 (1.04 to 1.50)0.0161.35 (1.15 to 1.58)3.0×10−40.94 (0.77 to 1.14)0.51
rs4073582CNIH-20.950.941.96 (1.30 to 2.95)1.2×10−31.51 (1.09 to 2.08)0.0131.26 (0.80 to 1.99)0.32
rs10791821MAP3K110.930.951.37 (0.96 to 1.96)0.0841.79 (1.26 to 2.54)1.2×10−30.79 (0.51 to 1.23)0.30
rs72552713§ABCG20.0670.0294.35 (2.82 to 6.72)3.0×10−111.28 (0.78 to 2.12)0.322.90 (1.77 to 4.75)2.4×10−5
rs2231142§ABCG20.500.383.37 (2.76 to 4.12)2.8×10−321.88 (1.58 to 2.24)2.5×10−121.76 (1.43 to 2.17)1.0×10−7
  • *We performed multivariate logistic regression analyses, in which all seven SNPs, alcohol drinking and body mass index were included in the model. In total, 1613 patients with gout and 1334 controls with genotypes for rs72552713 and rs2231142 of ABCG2, which were not on the Illumina OmniExpress platform, were used. Also, 375 and 509 patients with gout were grouped into ROL type and RUE type, respectively.

  • †dbSNP rs number.

  • ‡p Values <0.05 are shown in bold.

  • §Non-synonymous SNPs (rs1260326, Leu446Pro; rs72552713, Gln126Ter; and rs2231142, Gln141Lys).

  • Freq., frequency of risk-associated allele; ROL, renal overload; RUE, renal underexcretion; SNP, single-nucleotide polymorphism.