Table 4

Number of participants with adverse events

Low-dose fish oilHigh-dose fish oil
Hospitalisations37 (36.6%)38 (37.6%)
Infection (all)66 (65.3%)71 (70.3%)
 Respiratory46 (45.5%)51 (50.5%)
 Ear1 (1.0%)4 (4.0%)
 Other19 (18.8%)16 (15.8%)
Gastrointestinal (all)62 (61.4%)67 (66.3%)
 Upset26 (25.7%)15 (14.9%)
 Reflux12 (11.9%)17 (16.8%)
 Nausea13 (12.9%)19 (18.8%)
 Diarrhoea5 (5.0%)8 (7.9%)
 Intolerance/other6 (5.9%)8 (7.9%)
Bleeding (all)4 (4.0%)1 (1.0%)
 Epistaxis1 (1.0%)0 (0.0%)
 Haemarthrosis0 (0.0%)1 (1.0%)
 Postoperative1 (1.0%)0 (0.0%)
 Rectal1 (1.0%)0 (0.0%)
 Minor1 (1.0%)0 (0.0%)
Thrombosis (all)1 (1.0%)1 (1.0%)
 Superficial leg vein1 (1.0%)0 (0.0%)
 Deep vein thrombosis0 (0.0%)1 (1.0%)
Cancer (all)9 (8.9%)12 (11.9%)
 Breast cancer1 (1.0%)1 (1.0%)
 Prostate cancer1 (1.0%)0 (0.0%)
 Non-melanotic skin Ca6 (5.9%)9 (8.9%)
 Melanoma1 (1.0%)0 (0.0%)
 Other cancer0 (0.0%)2 (2.0%)
Cardiovascular (all)16 (15.8%)18 (17.8%)
 Sudden cardiac death1 (1.0%)0 (0.0%)
 Acute coronary syndrome10 (9.9%)10 (9.9%)
 Palpitations/atrial fibrillation4 (4.0%)4 (4.0%)
 Uncontrolled hypo/hypertension1 (1.0%)3 (3.0%)
 Pulmonary oedema0 (0.0%)1 (1.0%)
Knee surgery (all)5 (5.0%)6 (5.9%)
 Study knee2 (2.0%)4 (4.0%)
 Non-study knee3 (3.0%)2 (2.0%)