Table 2

Change in clinical parameters in the first 6 months

Baseline2 months4 months6 months
Proteinuria (g/day)
 p Value*0.310.150.270.58
Urine P/Cr ratio
 p Value*
CrCl (mL/min)
 p Value*0.540.01<0.0010.001
Serum albumin (g/L)
 p Value*0.110.980.220.26
C3 (g/L)
 p Value*0.820.320.450.90
Anti-dsDNA (IU/L)
 p Value*0.050.310.940.81
Active cellular cast
 MMF31 (41%)2 (3%)
 TAC31 (42%)5 (7%)
 p Value*0.890.27
Urine RBC >5/HPF
 MMF54 (71%)23 (30%)
 TAC58 (78%)26 (35%)
 p Value*0.300.53
 p Value*0.780.25
Extra-renal SLEDAI
 p Value*0.040.22
LDLc/HDLc ratio
 p Value*0.440.22
  • *p Value (comparison between MMF and TAC, with adjustment of baseline values by analysis of covariance at time points 2, 4 and 6 months).

  • CrCl, creatinine clearance; HDLc, high-density lipoprotein cholesterol; HPF, high power field; IU, international unit; LDLc, low-density lipoprotein cholesterol; MMF, mycophenolate mofetil; P/Cr, protein to creatinine; RBC, red blood cell; SLEDAI, systemic lupus erythematosus disease activity index; TAC, tacrolimus.