Univariate analysis of the ability of specific variables to distinguish patients with macrophage activation syndrome from comparison patients, as assessed using the 391 patients for whom expert consensus was achieved
No. of patients with available data | OR (95% CI) | p Value | |
---|---|---|---|
Clinical features | |||
Central nervous system involvement | 385 | 8.1 (4.5 to 14.4) | <0.0001 |
Hepatomegaly | 389 | 7.7 (4.5 to 12.9) | <0.0001 |
Haemorrhagic manifestations | 386 | 6.5 (3.3 to 12.8) | <0.0001 |
Fever | 388 | 5.4 (0.7 to 40.9) | 0.106 |
Splenomegaly | 386 | 4.6 (2.8 to 7.6) | <0.0001 |
Lymphadenopathy | 383 | 3.4 (2.1 to 5.5) | <0.0001 |
Kidney involvement | 390 | 3.5 (1.7 to 7.4) | 0.0008 |
Heart involvement | 388 | 3.1 (1.7 to 5.5) | 0.0001 |
Lung involvement | 389 | 2.5 (1.4 to 4.4) | 0.0011 |
Active arthritis | 390 | 1.6 (1.0 to 2.6) | 0.0587 |
Laboratory features | |||
Non-normalised values | |||
Ferritin >684 ng/mL | 334 | 111.6 (26.7 to 465.8) | <0.0001 |
Platelet count ≤181×109/L | 385 | 84.3 (40 to 177.5) | <0.0001 |
Aspartate aminotransferase >48 units/L | 377 | 51.9 (21.7 to 124.4) | <0.0001 |
Lactate dehydrogenase >853 units/L | 329 | 20.0 (10.7 to 37.3) | <0.0001 |
Triglycerides >156 mg/dL | 272 | 19.6 (9.4 to 40.8) | <0.0001 |
Alanine aminotransferase >36 units/L | 375 | 18.0 (9.4 to 34.3) | <0.0001 |
Fibrinogen ≤360 mg/dL | 314 | 11.5 (6.3 to 21.0) | <0.0001 |
Neutrophil count ≤3.7×109/L | 318 | 5.9 (3.4 to 10.5) | <0.0001 |
D-dimer >1350 ng/mL | 142 | 5.7 (2.4 to 13.4) | <0.0001 |
Erythrocyte sedimentation rate ≤30 mm/h | 335 | 5.6 (3.3 to 9.5) | <0.0001 |
Albumin ≤3.6 gm/dL | 331 | 5.5 (3.0 to 10.1) | <0.0001 |
Haemoglobin ≤8.5 gm/dL | 384 | 4.9 (2.7 to 8.8) | <0.0001 |
Leucocyte count ≤10.2×109/L | 384 | 4.6 (2.8 to 7.5) | <0.0001 |
Serum sodium ≤133, mEq/L | 339 | 2.9 (1.7 to 5.0) | 0.0002 |
C reactive protein >0.86 mg/dl | 367 | 2.4 (1.0 to 5.9) | 0.0501 |
Normalised values | |||
Ferritin >2773.6 ng/mL | 334 | 23.9 (12.7 to 44.8) | <0.0001 |
Aspartate aminotransferase >44.4 units/L | 377 | 47.4 (21.6 to 103.9) | <0.0001 |
Alanine aminotransferase >23 units/L | 375 | 39.4 (14.1 to 110.5) | <0.0001 |
Lactate dehydrogenase >238.8 units/L | 329 | 39.2 (18.2 to 84.6) | <0.0001 |
Triglycerides >193.9 mg/dL | 272 | 16.3 (8.7 to 30.8) | <0.0001 |
Fibrinogen ≤318.9 mg/dL | 314 | 11.0 (6.1 to 20.0) | <0.0001 |
Albumin ≤3.9 gm/dL | 331 | 6.4 (3.6 to 11.3) | <0.0001 |
D-dimer >1320.3 ng/mL | 142 | 5.2 (2.1 to 12.7) | <0.0001 |
Serum sodium ≤135 mEq/L | 339 | 3.3 (1.9 to 5.6) | <0.0001 |