Table 3

Synovial tissue volume and pain: baseline, follow-up and final visits, split by response type

VariableBaseline, mean (SD)Follow-up, mean (SD)Final Visit, mean (SD)Difference; Baseline to follow-up VisitDifference; Follow-up to final Visit
Mean (95% CI)Mean (95% CI)
(A) Initial responders, whose pain recurred within 6 months (‘Relapsers’)
 Synovitis volume (mm3)10 319 (5419)8609 (5517)9829 (5048)−1710 (−2904 to −515)1220 (25 to 2414)
 Synovial fluid volume (mm3)10 023 (5408)8690 (5514)9860 (5152)−1334 (−2555 to −113)1170 (−51 to 2391)
 KOOS pain subscale score (0–100)45.1 (13.6)75.57 (14.7)47.89 (17.1)30.42 (26.1 to 34.7)−27.7 (−32.0 to −23.4)
 Pain on nominated activity VAS (0–10)6.5 (1.5)1.99 (1.8)6.41 (2.3)−4.5 (−5.2 to −3.8)4.4 (3.7 to 5.1)
(B) Initial responders, whose pain did not recur within 6 months (‘Persistent responders’)
 Synovitis volume (mm3)8627 (5308)7782 (4436)7580 (5401)−845 (−2651 to 961)−202 (−2008 to 1604)
 Synovial fluid volume (mm3)8676 (5602)8322 (5407)7663 (5323)−355 (−2201 to 1491)−658 (−2504 to 1188)
 KOOS pain subscale score (0–100)42.9 (15.9)83.9 (12.5)73.3 (17.7)41.0 (34.3 to 47.8)−10.6 (−17.3 to −3.9)
 Pain on nominated activity VAS (0–10)6.5 (1.6)2.4 (2.2)3.6 (2.5)−4.1 (−5.2 to −3.0)1.3 (0.2 to 2.4)
  • KOOS, Knee Injury and Osteoarthritis Outcome Score; VAS, Visual Analogue Scale.