Predictor | PBMCs | CD4+CD45RA+ | CD8+CD45RA+ | |||
---|---|---|---|---|---|---|
Regression coeff | p Value | Regression coeff | p Value | Regression coeff | p Value | |
Age | −0.101 | <0.001 | −0.099 | <0.001 | −0.095 | <0.001 |
Sex | 0.657 | 0.031 | 0.712 | 0.014 | 0.701 | 0.030 |
Diagnosis aSpA | −3.442 | 0.004 | −2.566 | 0.023 | −2.651 | 0.034 |
Diagnosis RA | −4.201 | <0.001 | −2.844 | 0.008 | −3.248 | 0.006 |
Interaction age–aSpA | 0.059 | 0.021 | 0.051 | 0.038 | 0.047 | 0.086 |
Interaction age–RA | 0.076 | 0.001 | 0.053 | 0.012 | 0.057 | 0.017 |
Ki67+ cells | −0.132 | 0.004 | −0.107 | 0.015 | −0.654 | 0.176 |
Multivariate regression analysis with TREC levels of PBMCs or naïve T-cell subsets (CD4+CD45RA+ and CD8+CD45RA+) of patients with aSpA and patients with RA as dependent variables as well as age, sex, diagnosis, interaction age*diagnosis and proliferating cells (as indicated by the prevalence of Ki67+ cells) as predictors. aSpA, axial spondyloarthritis; PBMCs, peripheral blood mononuclear cells; RA, rheumatoid arthritis; TREC, T-cell receptor excision circle.