TableĀ 3

Predictors of skin progression as determined by univariate and multivariate analyses

Baseline characteristicsUnivariate analysisMultivariate analysis
p ValueHR (95% CI)p ValueHR (95% CI)
Age (years)0.1100.98 (0.97 to 1.02)NANA
Women (n=1037)0.2520.75 (0.47 to 1.21)NANA
Time since diagnosis (years)0.2010.79 (0.67 to 1.05)NANA
Joint synovitis (n=234)<0.0011.99 (1.21 to 1.43)0.0241.67 (1.06 to 2.64)
TFRs (n=166)<0.0012.23 (1.25 to 4.03)0.0351.69 (1.02 to 2.77)
Diffuse cutaneous subset (n=489)0.0211.58 (1.07 to 2.11)0.9430.98 (0.65 to 1.50)
Positive for antitopoisomerase-I antibodies (n=450)<0.0012.10 (1.41 to 3.12)0.0301.72 (1.09 to 2.62)
History of digital ulcers (n=354)0.0031.42 (1.02 to 2.15)0.0491.50 (1.01 to 2.23)
Lung fibrosis (n=355)0.7860.94 (0.73 to 1.51)NANA
DLCO <75% predicted (n=468)0.0781.32 (0.95 to 1.79)NANA
Elevated acute phase reactants (n=301)0.4071.20 (0.78 to 1.85)NANA
  • Age, sex, time since diagnosis, cutaneous subset, lung fibrosis, reduced DLCO and acute phase reactants were systematically assessed as covariates in univariate analysis, together with joint synovitis and TFRs. This table also mentions all other variables that have been identified as predictors in univariate analysis.

  • NA, not applicable; TFRs, tendon friction rubs.