Table 2

Differences between subfertile and fertile female patients with rheumatoid arthritis

VariableSubfertility*
YesNop Value
(n=104)(n=141)
Age, years31.9±4.330.8±3.50.029†
Nulliparity, n (%)67 (64)76 (54)0.116‡
Smoking, n (%)15 (14)19 (13)0.853‡
Duration of RA, years3.7 (1.1–8.8)3.4 (1.5–7.9)0.589§
RF positive, n (%)83 (80)97 (69)0.058‡
ACPA positive, n (%)76 (73)85 (60)0.042‡
Erosions present, n (%)52 (50)70 (50)1.000‡
MTX in the past, n (%)67 (64)94 (67)0.786‡
Biologicals in the past, n (%)16 (15)21 (15)0.527‡
DAS284.01±1.163.47±1.10<0.001†
NSAIDs, n (%)35 (34)25 (18)0.007‡
Prednisone, n (%)46 (44)35 (25)0.002‡
Sulfasalazine, n (%)35 (34)44 (31)0.782‡
Spontaneous abortion, n (%)11 (11)15 (11)1.000‡
  • *Subfertility is defined as a time to pregnancy >12 months. Values are given as mean±SD, median (IQR) and n (%).

  • †Student t test.

  • ‡Fisher's exact test.

  • §Mann–Whitney U test.

  • ACPA, anti-citrullinated peptide antibodies; DAS28, 28-joint Disease Activity Score; MTX, methotrexate; NSAIDs, non-steroidal anti-inflammatory drugs; RA, rheumatoid arthritis; RF, rheumatoid factor.