Table 4

Results for outcome absence of joint damage*

Baseline predictors (within 6 months after diagnosis)Number of studies
<†NSS†>†+References
Demographics
 Gender: female241, 44
 Ethnicity: Hispanic0/143
 Ethnicity: North American native148
 Higher age at onset0/121/041, 44, 45, 48
 Longer time from onset to diagnosis144
 Diagnosis at first visit144
JIA category
 Oligoarticular persistent
 Oligoarticular extended
 Systemic11/041, 48
 Poly RF-2/11/041, 44, 45, 48
 Poly RF+2/11/041, 44, 45, 48
 Psoriatic
 ERA
 Undifferentiated
Disease activity
 Higher active joint count11/041, 44
 Higher PGA1/044
 Cervical involvement1/041
 Wrist involvement1/041
 Finger joint involvement1/041
 Hip involvement1/041
 Ankle and/or wrist involvement141, 47
 Symmetric involvement241, 47
Laboratory
 ANA positive144
 RF positive10/141, 45
 Higher ESR2/141, 44, 46
 Higher number of months with elevated ESR (in first 6 months)141
 Higher CRP1/044
 Higher number of platelets1/044
Genetics
 HLA-B27 positive144
 HLA-DPB1*021/041
 TGF-β1 codon 25G/G (wild type)148
 IL-10 -1082G→A genotypes1/048
  • *Values are the number of studies that found that particular result for the respective predictors. †The first number in this column refers to the number of studies that performed a multivariate analysis disconfirming the univariate finding (studies in which the multivariate analysis confirmed the univariate finding, are shown in the columns labelled − and +, respectively). The second number in this column refers to the number of studies that did not perform a multivariate analysis. ‡In studies that evaluated onset categories oligoarticular, polyarticular and systemic, results have been duplicated for oligoarthritis persistent and extended, and polyarthritis RF-positive and RF-negative, respectively. −, lower chance of favourable outcome in multivariate analysis (p≤0.05); <, lower chance of favourable outcome in univariate analysis (p≤0.05); NS, not significant (p>0.05); S, significant in univariate analysis. Direction of the effect not shown (p≤0.05); >, higher chance of favourable outcome in univariate analysis (p≤0.05); +, higher chance of favourable outcome in multivariate analysis (p≤0.05).

  • ANA, antinuclear antibodies; CRP, C-reactive protein; ERA, enthesitis-related arthritis; ESR, erythrocyte sedimentation rate; HLA, human leucocyte antigens; IL, interleukin; JIA, Juvenile idiopathic arthritis; PGA, physician's global assessment; RF, rheumatoid factor; TGF, transforming growth factor.