Results for outcome absence of joint damage*
Baseline predictors (within 6 months after diagnosis) | Number of studies | ||||||
---|---|---|---|---|---|---|---|
− | <† | NS | S† | >† | + | References | |
Demographics | |||||||
Gender: female | 2 | 41, 44 | |||||
Ethnicity: Hispanic | 0/1 | 43 | |||||
Ethnicity: North American native | 1 | 48 | |||||
Higher age at onset | 0/1 | 2 | 1/0 | 41, 44, 45, 48 | |||
Longer time from onset to diagnosis | 1 | 44 | |||||
Diagnosis at first visit | 1 | 44 | |||||
JIA category‡ | |||||||
Oligoarticular persistent | |||||||
Oligoarticular extended | |||||||
Systemic | 1 | 1/0 | 41, 48 | ||||
Poly RF- | 2/1 | 1/0 | 41, 44, 45, 48 | ||||
Poly RF+ | 2/1 | 1/0 | 41, 44, 45, 48 | ||||
Psoriatic | |||||||
ERA | |||||||
Undifferentiated | |||||||
Disease activity | |||||||
Higher active joint count | 1 | 1/0 | 41, 44 | ||||
Higher PGA | 1/0 | 44 | |||||
Cervical involvement | 1/0 | 41 | |||||
Wrist involvement | 1/0 | 41 | |||||
Finger joint involvement | 1/0 | 41 | |||||
Hip involvement | 1/0 | 41 | |||||
Ankle and/or wrist involvement | 1 | 41, 47 | |||||
Symmetric involvement | 2 | 41, 47 | |||||
Laboratory | |||||||
ANA positive | 1 | 44 | |||||
RF positive | 1 | 0/1 | 41, 45 | ||||
Higher ESR | 2/1 | 41, 44, 46 | |||||
Higher number of months with elevated ESR (in first 6 months) | 1 | 41 | |||||
Higher CRP | 1/0 | 44 | |||||
Higher number of platelets | 1/0 | 44 | |||||
Genetics | |||||||
HLA-B27 positive | 1 | 44 | |||||
HLA-DPB1*02 | 1/0 | 41 | |||||
TGF-β1 codon 25G/G (wild type) | 1 | 48 | |||||
IL-10 -1082G→A genotypes | 1/0 | 48 |
*Values are the number of studies that found that particular result for the respective predictors. †The first number in this column refers to the number of studies that performed a multivariate analysis disconfirming the univariate finding (studies in which the multivariate analysis confirmed the univariate finding, are shown in the columns labelled − and +, respectively). The second number in this column refers to the number of studies that did not perform a multivariate analysis. ‡In studies that evaluated onset categories oligoarticular, polyarticular and systemic, results have been duplicated for oligoarthritis persistent and extended, and polyarthritis RF-positive and RF-negative, respectively. −, lower chance of favourable outcome in multivariate analysis (p≤0.05); <, lower chance of favourable outcome in univariate analysis (p≤0.05); NS, not significant (p>0.05); S, significant in univariate analysis. Direction of the effect not shown (p≤0.05); >, higher chance of favourable outcome in univariate analysis (p≤0.05); +, higher chance of favourable outcome in multivariate analysis (p≤0.05).
ANA, antinuclear antibodies; CRP, C-reactive protein; ERA, enthesitis-related arthritis; ESR, erythrocyte sedimentation rate; HLA, human leucocyte antigens; IL, interleukin; JIA, Juvenile idiopathic arthritis; PGA, physician's global assessment; RF, rheumatoid factor; TGF, transforming growth factor.