Frequency of PTPN22 R620W in the cohort of healthy subjects, disease control subjects and patients with RA
| PTPN22 R620W genotype | Healthy individuals (n=107) | RA patients (n=380) | RA patients (n=397)* | Odds ratio for genotype (95% CI) HI vs RA | p value |
|---|---|---|---|---|---|
| Control (GG) | 79% (n=85) | 75% (n=284) | 68% (n=272) | – | – |
| Heterozygote (AG) | 20% (n=21) | 23% (n=87) | 30% (n=119) | 1.31 (0.811 to 1.882) | 0.372 |
| Homozygote (AA) | 1% (n=1) | 2% (n=9) | 2% (n=6) | 2.11 (0.187 to 23.73) | 0.615 |
*Genotype frequency of PTPN22 R620W from Toms et al20 for comparative purposes. Differences in genotype frequency between healthy individuals and patients with RA were analysed using Fisher's exact test with a two-tailed p value with additional calculation of OR. There were no significant differences in genotype frequency when comparing healthy individuals and patients with RA.
HI, healthy individuals; RA, rheumatoid arthritis.