Table 3

Recommendation 3: summary of studies on the use of MRI in monitoring disease activity in axial spondyloarthritis

StudiesNo.RegionMRI scoring methodASDASBASDAICRPESRPain
 Marzo-Ortega et al2076SpineLEEDSNSNSNS
 Oostveen et al2125SIJmNY  OR 2.1OR 2.1OR 1.2
 Baraliakos et al5040SpineASspiMRI-aNSNSNS
 Bonel et al5228SpineASspiMRI-a0.41
 Braun et al5320SpineASspiMRI-a/c0.49–0.6
 Braun et al5498SpineASspiMRI-a0.35NS0.4NS
 Lambert 20076182Spine/SIJSPARCCNSp=0.018NS
 Machado et al63221SpineASspiMRI-a0.14NS
 Machado et al64221SpineASspiMRI-a0.23NS0.32
 Maksymowych et al6668SpineSPARCCNS0.65–0.68NS
 Maksymowych et al6736SpineSPARCCNS0.450.44
 Marzo-Ortega et al6842Spine/SIJLEEDSp=0.04
 Pedersen et al6982Spine/SIJBerlin0.46/0.31−0.41/−0.31NS
 Puhakka et al7134SIJBMENS
 Rudwaleit et al7362Spine/SIJBerlinNSNSNSNS
 Sieper et al7420SpineASspiMRI-a0.5NSNS
 Song et al7676Spine/SIJASspiMRI-a/Berlinp=0.04NS
 Visvanathan et al77279SpineASspiMRI-ap<0.001
 Blachier 201351648Spine/SIJDichotomousaOR 1.71–2.86
 Goh et al5534SpineASspiMRI-aNSNSNS
 Kiltz et al59100Spine/SIJBerlinNSNS0.22
 Konca et al6050SpineASspiMRI-a0.37NS0.330.39
 Puhakka et al7041SIJBME enhancementNS
 Weber et al79197ACWDichotomousκ 0.21–0.33
  • The Spearman test for rank correlation is used for test of correlation, values are correlation coefficients (rho), if not otherwise indicated. p Values indicate the level of statistical significance.

  • aOR, adjusted odd ratio; ACW, anterior chest wall; AS, ankylosing spondylitis; ASDAS, Ankylosing Spondylitis Disease Activity Score; ASspiMRI-a/c, ankylosing spondylitis spine MRI score for activity; BASDAI, Bath Ankylosing Spondylitis Disease Activity Score; BME, bone marrow oedema; CRP, C-reactive protein; ESR, erythrocyte sedimentation rate; LEEDS, Leeds MRI scoring system; mNY, modified New York; MRI, magnetic resonance imaging; No., number of individuals included in the study; NS, not statistically significant; OR, odds ratio; RCT, randomised controlled trial; SIJ, sacroiliac joints; SPARCC, Spondyloarthritis Research Consortium of Canada Scoring System; –, not done.