Renal response of pure membranous lupus nephritis
| Baseline | 2 months | 4 months | 6 months | p Value | |
|---|---|---|---|---|---|
| Urine P/Cr ratio | |||||
| MMF | 6.32±8.2 | 2.95±3.2 | 2.50±2.1 | 1.45±1.1 | 0.047 |
| TAC | 4.34±2.8 | 1.44±1.1 | 1.85±2.9 | 1.08±0.9 | <0.001 |
| p Value* | 0.44 | 0.16 | 0.65 | 0.52 | |
| CrCl (mL/min) | |||||
| MMF | 92.4±36 | 93.5±35 | 104±37 | 102±31 | 0.19 |
| TAC | 100±38 | 98.8±43 | 90.9±41 | 90.8±44 | 0.07 |
| p Value* | 0.57 | 0.76 | 0.03 | 0.04 | |
| Renal response at 6 months | MMF (N=12) | TAC (N=16) | Difference (95% CI)† | p Value |
|---|---|---|---|---|
| CR | 6 (50%) | 9 (56%) | 6% (−27% to 38%) | 0.09 |
| PR | 3 (25%) | 7 (44%) | 19% (−16% to 47%) | |
| NR | 3 (25%) | 0 (0%) | −25% (−53% to 0.2%) |
*p Value (comparison between MMF and TAC, with adjustment of baseline values by analysis of covariance at time points 2, 4 and 6 months).†With reference to MMF.CR, complete response; CrCl, creatinine clearance; MMF, mycophenolate mofetil; NR, no response; P, (comparison between month 6 values with baseline); P/Cr, protein to creatinine; PR, partial response; TAC, tacrolimus.