Allele and haplotype associations with propensity for more severe psoriatic arthritis phenotype based on the presence of enthesitis, dactylitis, sacroiliitis, joint deformity, joint fusion, erosion and osteolysis
| PsA severity propensity tertile | ||||||
|---|---|---|---|---|---|---|
| Lower | Middle | Higher | p Value | |||
| n=176 | n=176 | n=170 | Lower vs higher | OR† | 95% CI | |
| Alleles | ||||||
| B*07:02:01 | 32 (18) | 29 (16) | 20 (12) | 0.095 | 0.60 | (0.33 to 1.10) |
| B*08:01:01 | 24 (14) | 42 (24) | 47 (28) | 0.001 | 2.42 | (1.40 to 4.18) |
| B*18:01:01 | 3 (2) | 4 (2) | 9 (5) | 0.082 | 3.22 | (0.86 to 12.1) |
| B*27:05:02 | 10 (6) | 15 (9) | 16 (9) | 0.19 | 1.72 | (0.76 to 3.92) |
| B*37:01:01 | 4 (2) | 5 (3) | 9 (5) | 0.17 | 2.40 | (0.73 to 7.96) |
| B*44:02:01:01 | 24 (14) | 13 (7) | 9 (5) | 0.008 | 0.35 | (0.16 to 0.79) |
| B*44:03:01 | 15 (9) | 6 (3) | 6 (4) | 0.070 | 0.39 | (0.15 to 1.04) |
| Any B*44 Alleles | 39 (22) | 19 (11) | 15 (9) | 0.001 | 0.34 | (0.18 to 0.64) |
| C*02:02:02 | 1 (1) | 8 (5) | 10 (6) | 0.005 | 10.94 | (1.38 to 86.4) |
| C*04:01:01:01 | 15 (9) | 14 (8) | 7 (4) | 0.093 | 0.46 | (0.18 to 1.16) |
| C*07:01:01 | 28 (16) | 46 (26) | 51 (30) | 0.002 | 2.27 | (1.35 to 3.81) |
| C*07:02:01:01 | 34 (19) | 33 (19) | 19 (11) | 0.036 | 0.53 | (0.29 to 0.96) |
| C*16:01:01 | 12 (7) | 2 (1) | 5 (3) | 0.095 | 0.41 | (0.14 to 1.20) |
| Haplotypes | ||||||
| B*07:02:01- C*07:02:01:01 | 32 (18) | 28 (16) | 19 (11) | 0.066 | 0.57 | (0.31 to 1.04) |
| B*08:01:01-C*07:01:01 | 24 (14) | 41 (23) | 46 (27) | 0.002 | 2.35 | (1.36 to 4.06) |
| B*27:05:02-C*02:02:02 | 1 (1) | 7 (4) | 9 (5) | 0.010 | 9.78 | (1.23 to 78.1) |
| B*37:01:0-C*06:02:01:01 | 4 (2) | 5 (3) | 9 (5) | 0.17 | 2.40 | (0.73 to 7.96) |
| B*44:03:01-C*16:01:01 | 12 (7) | 1 (1) | 5 (3) | 0.095 | 0.41 | (0.14 to 1.20) |
All values are n (%) unless otherwise indicated.
†OR indicates relationship between higher vs lower propensity.
PsA, psoriatic arthritis.