Table 2

Cumulative probability of comorbidity after diagnosis of gout

	Patients with incident gout					Controls
	At diagnosis	1 year	2 years	5 years	10 years	At diagnosis	1 year	2 years	5 years	10 years	p Value
Charlson index ≥1	38.25	42.09	45.39	53.99	66.27	27.97	30.78	33.32	40.91	51.54	<0.001
Any increase in Charlson index	0	3.88	7.30	16.60	31.19	0	3.80	6.95	14.54	23.24	<0.001
Neoplasms
Solid malignancy, leukaemia and lymphoma	5.35	6.47	7.76	11.84	19.44	4.49	5.54	6.56	10.27	16.76	<0.001
Metastatic solid tumours	0.14	0.30	0.51	1.05	2.08	0.16	0.33	0.49	0.97	1.88	0.266
Cardiovascular diseases
Hypertension	34.81	38.46	41.58	49.62	59.64	18.70	21.28	23.85	30.50	39.19	<0.001
Cardiac arrhythmias	8.80	9.93	11.00	14.01	19.10	3.72	4.30	5.02	6.95	10.64	<0.001
Cerebrovascular disease	5.99	7.02	7.95	10.46	14.48	4.13	4.92	5.57	7.65	10.74	<0.001
Congestive heart failure	8.54	9.49	10.30	12.04	14.59	2.35	2.87	3.28	4.37	6.03	<0.001
Myocardial infarction	5.47	6.12	6.63	8.15	10.54	2.76	3.23	3.57	4.86	6.87	<0.001
Peripheral vascular disease	3.85	4.43	4.93	6.23	8.35	2.36	2.65	2.92	3.92	5.49	<0.001
Valvular heart disease	2.27	2.60	2.96	3.94	5.71	0.96	1.12	1.29	1.78	2.87	<0.001
Genitourinary diseases
Urolithiasis	0.94	1.05	1.14	1.42	1.99	0.66	0.73	0.82	1.07	1.42	<0.001
Renal diseases	3.05	4.20	5.30	8.50	12.51	0.54	0.76	1.07	2.22	4.04	<0.001
Metabolic and endocrine diseases
Uncomplicated diabetes mellitus	7.08	8.37	9.66	13.87	20.87	5.83	6.46	7.11	9.21	12.50	<0.001
Diabetes mellitus with complications	1.30	1.64	2.03	3.60	13.92	1.13	1.43	1.71	2.79	8.41	<0.001
Hyperlipidaemia	10.11	11.75	13.23	17.10	22.05	5.37	6.30	7.28	10.04	13.94	<0.001
Hypothyroidism	3.61	4.15	4.68	6.22	8.29	2.23	2.60	2.95	4.03	5.58	<0.001
Gastrointestinal and hepatic diseases
Peptic ulcer disease	2.02	2.33	2.54	3.10	3.88	1.78	1.96	2.11	2.50	3.14	<0.001
Mild liver disease	0.39	0.52	0.62	1.11	1.99	0.29	0.35	0.40	0.60	0.94	<0.001
Moderate to severe liver disease	0.08	0.10	0.11	0.21	0.43	0.07	0.08	0.10	0.18	0.30	0.002
Chronic pulmonary diseases	13.59	14.70	15.62	18.20	22.02	9.83	10.57	1.44	13.66	17.15	<0.001
Musculoskeletal and connective tissue diseases
Osteoarthritis	10.91	12.71	14.24	18.30	24.00	7.80	8.83	9.77	12.47	16.55	<0.001
Rheumatological disease	7.12	8.46	9.72	12.94	18.78	6.12	6.77	7.37	9.22	12.31	<0.001
Neurological and mental disorders
Dementia	0.30	0.46	0.65	1.29	2.97	0.56	0.79	1.02	1.79	3.76	<0.001
Hemiplegia	0.39	0.48	0.55	0.6	1.03	0.37	0.44	0.46	0.64	0.80	0.007
Multiple sclerosis	0.08	0.09	0.09	0.11	0.13	0.15	0.16	0.17	0.19	0.23	0.003
Other neurological diseases	1.77	2.17	2.53	3.62	5.30	2.17	2.51	2.84	3.84	5.65	0.071
Psychosis	0.40	0.49	0.55	0.75	1.16	0.24	0.61	0.68	0.93	1.27	0.234
Depression	12.10	13.60	14.97	18.90	24.74	10.39	11.45	12.59	15.76	20.59	<0.001
Other comorbidities
Anaemia	8.84	1.45	11.75	16.11	23.43	5.86	6.68	7.55	10.43	15.55	<0.001
Psoriasis	3.20	3.53	3.81	4.63	5.81	2.24	2.40	2.61	3.12	3.85	<0.001
HIV infection	0.03	0.03	0.04	0.04	–	<0.001	–	–	0.03	–	0.027

Figures are probability of incident comorbidity (percentage).