Effect of autologous adipose-derived stromal vascular fraction injection on hand disability
| Baseline | 2 months | Change (2 months–baseline) | p Value* | 6 months | Change (6 months–baseline) | p Value† | |
|---|---|---|---|---|---|---|---|
| CHFS total | |||||||
| Mean±SD | 48.5±10.8 | 25.8±17.0 | −22.7±16.4 | <0.001 | 21.2±15.4 | −27.3±17.2 | <0.001 |
| Median (range) | 48.5 (30–69) | 25.5 (2–49) | −22.5 (−51–10) | 20.0 (0–48) | −30.0 (−58–10) | ||
| Jamar score (kg) | |||||||
| Dominant hand | |||||||
| Mean±SD | 16.0±5.8 | 17.9±7.3 | 3.0±5.0 | 0.072 | 19.4±7.4 | 4.8±6.4 | 0.033 |
| Median (range) | 15.0 (9.0–26.5) | 18.5 (5.5–28.0) | 2.0 (−3.0–15.0) | 20.0 (5.0–30.0) | 3.0 (−6.0–17.0) | ||
| Non-dominant hand | |||||||
| Mean±SD | 14.9±6.1 | 17.5±7.8 | 3.7±3.6 | 0.006 | 17.6±8.0 | 4.0±3.5 | 0.002 |
| Median (range) | 14.0 (6.0–26.0) | 18.5 (4.0–28.0) | 3.0 (−2.0–9.0) | 20.0 (3.5–29.0) | 3.0 (0.0–13.0) | ||
| Pinch score (kg) | |||||||
| Dominant hand | |||||||
| Mean±SD | 1.3±1.1 | 2.0±0.8 | 0.6±1.3 | 0.199 | 2.3±1.3 | 1.0±1.1 | 0.009 |
| Median (range) | 0.9 (0.2–4.1) | 2.3 (0.5–3.2) | 0.8 (−2.3–2.7) | 2.0 (0.9–5.4) | 0.9 (−1.1–3.4) | ||
| Non-dominant hand | |||||||
| Mean±SD | 1.3±0.9 | 2.2±0.7 | 0.7±1.2 | 0.071 | 2.1±1.0 | 0.8±1.2 | 0.050 |
| Median (range) | 0.9 (0.2–3.2) | 2.3 (1.4–3.2) | 0.5 (−0.9–2.5) | 2.0 (0.7–3.6) | 0.5 (−1.1–3.4) | ||
| Kapandji score/10 | |||||||
| Dominant hand | |||||||
| Mean±SD | 8.0±1.4 | 8.3±1.6 | 0.3±1.0 | 0.380 | 8.4±1.7 | 0.5±0.9 | 0.111 |
| Median (range) | 8.0 (5.0–10.0) | 9.0 (5.0–10.0) | 0.0 (−1.0–2.5) | 9.3 (5.0–10.0) | 0.0 (−1.0–2.5) | ||
| Non-dominant hand | |||||||
| Mean±SD | 8.5±1.2 | 8.4±1.6 | −0.1±0.7 | 1.000 | 8.8±1.3 | 0.4±0.7 | 0.188 |
| Median (range) | 9.0 (6.0–10.0) | 9.0 (5.0–10.0) | 0.0 (−1.0–1.5) | 9.0 (6.0–10.0) | 0.0 (−0.5–2.0) | ||
| 1st corner distance (mm) | |||||||
| Dominant hand | |||||||
| Mean±SD | 105.6±24.7 | 112.9±29.2 | 7.3±8.2 | 0.010 | 118.9±31.2 | 13.3±11.6 | 0.002 |
| Median (range) | 112.0 (57–142) | 118.5 (57–154) | 5.5 (−6–23) | 124.0 (58–178) | 10.0 (−3–36) | ||
| Non-dominant hand | |||||||
| Mean±SD | 115.8±24.5 | 122.3±20.9 | 6.5±9.8 | 0.042 | 132.8±28.0 | 17.0±14.7 | 0.002 |
| Median (range) | 118.5 (65–152) | 121.5 (88–155) | 4.5 (−8–23) | 137.0 (95–190) | 15.5 (−4–38) | ||
| Sum of corners distances (mm) | |||||||
| Dominant hand | |||||||
| Mean±SD | 133.9±18.5 | 131.2±20.7 | 1.0±13.7 | 0.822 | 140.2±26.6 | 9.8±15.3 | 0.073 |
| Median (range) | 130.5 (110–168) | 131.0 (94–169) | 2.0 (−18–28) | 131.0 (105–188) | 5.5 (−7–36) | ||
| Non-dominant hand | |||||||
| Mean±SD | 132.1±24.6 | 133.7±29.4 | 4.5±6.8 | 0.052 | 137.9±27.0 | 8.3±5.1 | <0.001 |
| Median (range) | 139.0 (73–158) | 139.5 (64–166) | 6.0 (−9–13) | 147.0 (77–177) | 10.0 (1–19) | ||
| Sum of Pad/DPL distance (mm) | |||||||
| Dominant hand | |||||||
| Mean±SD | 52.0±46.5 | 47.3±43.8 | −4.8 ±18.6 | 0.395 | 43.9±42.7 | −8.1±16.2 | 0.111 |
| Median (range) | 49.5 (0–160) | 45.0 (0–115) | −2.5 (−45–23) | 36.5 (0–125) | −4.0 (−35–19) | ||
| Non-dominant hand | |||||||
| Mean±SD | 48.1±54.5 | 46.8±52.0 | −1.3±19.6 | 0.830 | 37.8±43.0 | −10.3±20.6 | 0.109 |
| Median (range) | 32.0 (0–144) | 38.5 (0–160) | −0.5 (−43–28) | 15.0 (0–111) | −2.0 (−41–22) | ||
Bold values correspond to the p value columns. p≤0.05 (2-sided) was considered significant.
Data are mean±SD, median (minimum–maximum).
*p Value from baseline to M2.
†p Value from baseline to M6.
CHFS, Cochin Hand Functional Scale; DPL, Distal Palmar Line.