Baseline characteristics of the study population
| Characteristic | Chondroitin sulfate+glucosamine hydrochloride (n=264)* | Celecoxib (n=258)* |
|---|---|---|
| Age (years) | 62.2±8.8 | 63.2±9.0 |
| Women | 229 (86.7) | 209 (81.0) |
| White | 260 (98.5) | 255 (98.8) |
| Body mass index (kg/m2) | 31.1±5.8 | 30.9±18.0 |
| Kellgren and Lawrence radiographic reading | ||
| Grade 2 | 165 (62.5) | 162 (62.8) |
| Grade 3 | 99 (37.5) | 96 (37.2) |
| Most common analgesics before inclusion | ||
| Acetaminophen | 74 (28.0) | 77 (29.8) |
| Ibuprofen | 45 (17.0) | 37 (14.3) |
| Diclofenac | 36 (13.4) | 40 (15.5) |
| WOMAC score (inclusion) | ||
| Pain scale | 372.0±41.8 | 370.6±41.4 |
| Stiffness scale | 130.2±35.0 | 129.5±37.2 |
| Function scale | 1131.4±242.7 | 1111.6±267.8 |
| Huskisson's visual analogue scale (pain intensity) | 72.8±15.1 | 73.5±15.1 |
| Joint swelling | 33 (12.5) | 36 (14) |
| Joint effusion | 18 (6.8) | 20 (7.8) |
| Patient's global assessment of disease activity | 69.1±17.3 | 69.4±16.4 |
| Investigator's global assessment of disease activity | 63.2±15.5 | 63.3±14.7 |
| EuroQol-5D (health-related quality of life) | ||
| Mobility | 1.8±0.4 | 1.8±0.4 |
| Self-care | 1.4±0.5 | 1.4±0.5 |
| Usual activities | 1.8±0.4 | 1.8±0.4 |
| Pain/discomfort | 2.3±0.4 | 2.3±0.4 |
| Anxiety/depression | 1.7±0.6 | 1.6±0.6 |
| Visual analogue scale | 54.5±20.3 | 52.5±20.7 |
Data are mean±SD or n (%).
*Continuous variables are mean±SD at baseline and baseline adjusted least-square means (95% CI) for other measurements; ordinal variables are mean±SD.
WOMAC, Western Ontario and McMaster osteoarthritis index.