Characteristics of patients with SSc versus age- and sex-matched cohorts
| Variables | SSc (n=1712) | Control (n=10 272) | p Value |
|---|---|---|---|
| Mean age at enrolment, years (SD) | 50.3 (14.4) | 50.3 (14.4) | 1 |
| Female, n (%) | 1332 (77.8) | 7992 (77.8) | 0.998 |
| Median follow-up years (IQR) | 5.2 (2.5 to 7.0) | 7.0 (7.0 to 7.0) | <0.001 |
| Osteoporotic fracture event, n (%; F:M) | |||
| Overall | 73 (4.3; 68:5) | 379 (3.7; 333:46) | 0.244 |
| Vertebral | 54 (3.2; 49:5) | 266 (2.4; 237:29) | 0.193 |
| Hip | 17 (1.0; 17:0) | 79 (0.8; 63:16) | 0.308 |
| Radius | 7 (0.4; 7:0) | 50 (0.5; 47:3) | 0.849 |
| Median age of osteoporotic fracture (IQR) | |||
| Overall | 66.8 (58.3 to 73.4) | 69.7 (60.7 to 76.4) | 0.049 |
| Vertebral | 67.9 (59.6 to 74.6) | 70.2 (61.3 to 76.2) | 0.309 |
| Hip | 67.2 (53.2 to 74.7) | 75.2 (68.4 to 78.7) | 0.005 |
| Radius | 59.3 (44.2 to 62.3) | 58.7 (51.7 to 64.9) | 0.576 |
| One-year mortality rate after fracture, n (%) | |||
| Overall | 9 (12.3) | 17 (4.5) | 0.023 |
| Vertebral | 7 (13.0) | 8 (3.0) | 0.006 |
| Hip | 2 (11.8) | 9 (11.4) | 1 |
| Radius | 1 (14.3) | 2 (4.0) | 0.330 |
F, female; M, male; SSc, systemic sclerosis.