Table 1

Clinical and laboratory parameters for APS, APS+SLE and SLE and controls cohorts at enrolment

Healthy donors (N=61)APS patients (N=41)p Value*APS+SLE patients (N=31)p Value*SLE patients (N=54)p Value*
Clinical parameters†
 Females/males43/1833/827/450/4
 Age (years)39.02±9.8648.53±11.58n.s.44.94±11.75n.s.36.48±11.80n.s.
 Anti-dsDNA1.41±2.5229.70±60.650.04021.06±29.120.001
 aCL IgG (GPL)4.34±7.5553.85±96.310.00313.66±25.450.0277.95±11.94n.s.
 aCL IgM (MPL)8.79±6.2328.78±51.170.02018.72±44.550.00910.70±47.96n.s.
 Anti-ß2GPI (SGU)5.65±8.8244.06±95.100.0053.56±6.60n.s.2.44±4.99n.s.
 LA positivity (%)029 (71%)15 (48%)13(24%)
 SLEDAI02.10±3.820.0211.56±2.190.001
 Thrombosis (%)028 (68%)28 (90%)2 (4%)
 Obesity (%)2 (3%)10 (24%)11 (35%)11 (20%)
 Hypertension (%)2 (3%)3 (7%)6 (19%)8 (15%)
 Diabetes (%)005(16%)1(2%)
 Nephropathy (%)007(23%)15(28%)
 Increased CIMT (%)3 (5%)13 (32%)10 (32%)11 (20%)
Corticosteroids (%)03 (7%)22 (71%)29 (54%)
Antimalarials (%)03 (7%)20(65%)32(59%)
Anticoagulants/antiplatelets (%)033 (80%)26 (84%)31 (57%)
Laboratory parameters†
 Total cholesterol (mg/dL)190.08±34.95191.65±35.89n.s.199.42±37.39n.s.180.25±30.100.010
 Cholesterol HDL (mg/dL)55.83±13.2152.53±15.08n.s.50.80±15.35n.s.54.82±13.42n.s.
 Cholesterol LDL (mg/dL)115.77±29.63114.62±30.88n.s.125.00±30.24n.s.107.57±24.830.015
 Triglycerides (mg/dL)89.87±53.33115.89±68.440.047129.03±50.160.00191.26±42.08n.s.
 C-reactive protein (mg/dL)2.34±5.416.11±10.830.0465.72±9.140.0012.47±3.530.019
 Apolipoprotein A (g/L)150.65±29.00135.83±22.040.030145.86±33.87n.s.146.80±27.31n.s.
 Apolipoprotein B (g/L)78.55±20.2286.08±19.23n.s.92.86±21.720.04975.38±16.92n.s.
 C3 (mg/dL)135.92±45.17123.54±33.58n.s.125.13±46.69n.s.110.54±29.580.001
 C4 (mg/dL)26.94±11.8223.06±7.89n.s.20.27±8.170.00518.32±8.750.001
  • *p<0.05 vs healthy donors.

  • †Except where otherwise indicated, values are the number of subjects and mean±SD.

  • aCL, anticardiolipin; APS, antiphospholipid syndrome; CIMT, carotid intimate media thickness; GPL IgG phospholipid units; HDL, high-density lipoprotein; LDL, low-density lipoprotein; MPL, IgM phospholipid units; SGU, standard IgG units; SLE, systemic lupus erythematosus; SLEDAI, Systemic Lupus Erythematosus Disease Activity Index.