HRs (95% CIs) for high-grade cervical dysplasia and cervical cancer
| Adjustment | SID* (n=133 333) | IBD (n=25 176) | Psoriasis (n=34 665) | RA (n=58 979) | SLE (n=14 513) | Non-SID* (n=533 332) |
|---|---|---|---|---|---|---|
| Unadjusted | 1.28 (1.11 to 1.47) | 1.50 (1.16 to 1.96) | 1.11 (0.85 to 1.45) | 1.13 (0.92 to 1.38) | 1.90 (1.38 to 2.61) | Referent |
| Age only | 1.27 (1.11 to 1.47) | 1.22 (0.94 to 1.59) | 1.00 (0.77 to 1.31) | 1.40 (1.14 to 1.72) | 1.66 (1.21 to 2.28) | |
| Model 1 | 1.24 (1.07 to 1.44) | 1.18 (0.90 to 1.55) | 0.98 (0.77 to 1.31) | 1.38 (1.12 to 1.71) | 1.61 (1.17 to 2.23) | |
| Model 2 | 1.27 (1.10 to 1.48) | 1.22 (0.93 to 1.60) | 0.99 (0.76 to 1.30) | 1.45 (1.17 to 1.79) | 1.57 (1.13 to 2.18) | |
| Model 3 | 1.23 (1.04 to 1.46) | 1.20 (0.91 to 1.58) | 0.99 (0.75 to 1.30) | 1.44 (1.11 to 1.88) | 1.56 (1.11 to 2.19) | |
| Model 4 | 1.18 (1.00 to 1.40) | 1.08 (0.80 to 1.46) | 0.97 (0.74 to 1.27) | 1.49 (1.14 to 1.95) | 1.54 (1.08 to 2.19) | |
| Model 5 (full model) | 1.16 (0.97 to 1.39) | 1.07 (0.79 to 1.45) | 0.96 (0.73 to 1.27) | 1.49 (1.11 to 2.00) | 1.53 (1.07 to 2.19) |
Model 1 is adjusted for age, comorbidity score and number of prescription drugs.
Model 2 is adjusted for alcoholism, smoking, substance abuse, being sexually active, diagnosis of sexually transmitted disease, oral and non-oral contraceptive use, receipt of HPV vaccine, diabetes, chronic kidney disease and liver disease, in addition to the variables in model 1.
Model 3 is adjusted for use of systemic immunosuppressive drugs, steroids and non-steroidal anti-inflammatory drugs, in addition to the variables in model 2.
Model 4 is adjusted for healthcare utilisation factors and preventive medical services, in addition to the variables in model 2.
Model 5 is adjusted for healthcare utilisation factors and preventive medical services, in addition to the variables in model 3.
*SID and non-SID cohorts are age- and index date-matched.
HPV, human papillomavirus; IBD, inflammatory bowel disease; RA, rheumatoid arthritis; SID, systemic inflammatory disease; SLE, systemic lupus erythematosus.