Table 3

HRs (95% CIs) for high-grade cervical dysplasia and cervical cancer

AdjustmentSID* (n=133 333)IBD (n=25 176)Psoriasis (n=34 665)RA (n=58 979)SLE (n=14 513)Non-SID* (n=533 332)
Unadjusted1.28 (1.11 to 1.47)1.50 (1.16 to 1.96)1.11 (0.85 to 1.45)1.13 (0.92 to 1.38)1.90 (1.38 to 2.61)Referent
Age only1.27 (1.11 to 1.47)1.22 (0.94 to 1.59)1.00 (0.77 to 1.31)1.40 (1.14 to 1.72)1.66 (1.21 to 2.28)
Model 11.24 (1.07 to 1.44)1.18 (0.90 to 1.55)0.98 (0.77 to 1.31)1.38 (1.12 to 1.71)1.61 (1.17 to 2.23)
Model 21.27 (1.10 to 1.48)1.22 (0.93 to 1.60)0.99 (0.76 to 1.30)1.45 (1.17 to 1.79)1.57 (1.13 to 2.18)
Model 31.23 (1.04 to 1.46)1.20 (0.91 to 1.58)0.99 (0.75 to 1.30)1.44 (1.11 to 1.88)1.56 (1.11 to 2.19)
Model 41.18 (1.00 to 1.40)1.08 (0.80 to 1.46)0.97 (0.74 to 1.27)1.49 (1.14 to 1.95)1.54 (1.08 to 2.19)
Model 5 (full model)1.16 (0.97 to 1.39)1.07 (0.79 to 1.45)0.96 (0.73 to 1.27)1.49 (1.11 to 2.00)1.53 (1.07 to 2.19)
  • Model 1 is adjusted for age, comorbidity score and number of prescription drugs.

  • Model 2 is adjusted for alcoholism, smoking, substance abuse, being sexually active, diagnosis of sexually transmitted disease, oral and non-oral contraceptive use, receipt of HPV vaccine, diabetes, chronic kidney disease and liver disease, in addition to the variables in model 1.

  • Model 3 is adjusted for use of systemic immunosuppressive drugs, steroids and non-steroidal anti-inflammatory drugs, in addition to the variables in model 2.

  • Model 4 is adjusted for healthcare utilisation factors and preventive medical services, in addition to the variables in model 2.

  • Model 5 is adjusted for healthcare utilisation factors and preventive medical services, in addition to the variables in model 3.

  • *SID and non-SID cohorts are age- and index date-matched.

  • HPV, human papillomavirus; IBD, inflammatory bowel disease; RA, rheumatoid arthritis; SID, systemic inflammatory disease; SLE, systemic lupus erythematosus.