Baseline demographics and clinical characteristics
| Baseline characteristics | |
|---|---|
| Sex, n (%) female | 67 (91) |
| Age, mean (SD) years | 67.9 (5.3) |
| Body Mass Index, mean (SD)(n=63) | 26.4 (3.8) |
| Fulfilling ACR criteria for hand OA, n (%) | 69 (93) |
| AUSCAN pain, mean (SD) (0–20 scale)(n=72) | 8.0 (3.9) |
| AUSCAN physical function, mean (SD) (0–36 scale) | 15.6 (8.0) |
| Grip strength dominant hand, mean (SD) kilograms(n=68) | 21 (8.1) |
| Radiographic findings (presented at joint level)* | |
| Radiographic hand OA (Kellgren–Lawrence)(n=592 joints in 74 participants) n (%) | |
| Grade 0 | 123 (20.8) |
| Grade 1 | 64 (10.8) |
| Grade 2 | 204 (34.5) |
| Grade 3 | 107 (18.1) |
| Grade 4† | 94 (15.9) |
| Radiographic joint space narrowing(n=592 joints in 74 participants) n (%) | |
| Grade 0 | 262 (44.3) |
| Grade 1 | 145 (24.5) |
| Grade 2 | 100 (16.9) |
| Grade 3† | 85 (14.4) |
| Radiographic erosions(n=536 joints in 67 women) n (%) | |
| Non-erosive | 438 (81.7) |
| Erosive† | 98 (18.3) |
| MRI findings (presented at joint level)‡ (%) | |
| Synovitis, n (n=511 in 65 patients) | 346 (67.7) |
| Flexor tenosynovitis, n (n=494 in 65 patients) | 96 (19.4) |
| Focal erosions, n (n=579 in 73 patients) | 290 (50.1) |
| Subchondral bone attrition, n (n=579 in 73 patients) | 113 (19.5) |
| Cysts, n (n=579 in 73 patients) | 24 (4.1) |
| Osteophytes (grades 2–3), n (n=582 in 73 patients) | 185 (31.8) |
| Joint space narrowing, n (n=582 in 73 patients) | 404 (69.4) |
| Bone marrow lesions, n (n=591 in 74 patients) | 73 (12.4) |
| Malalignment, n (n=583 in 73 patients) | 38 (6.5) |
| Collateral ligament discontinuity, n (n=582 in 73 patients) | 327 (56.2) |
*Eight joints (2nd–5th distal and proximal interphalangeal joints (n=8) in the dominant hand) for each of the n=74 participants (n=67 women in the analyses on erosive evolution).
†Excluded from the Generalised Estimating Equation analyses.
‡Eight joints (2nd–5th distal and proximal interphalangeal joints (n=8) in the dominant hand) for each of the n=74 participants (n=67 women in the analyses on erosive evolution). Missing information for certain MRI features if the joint was not completely covered by the field of view, severe deformities and/or no T1-weighted pre-Gadolinium or post-Gadolinium sequence.
ACR, American College of Rheumatology; AUSCAN, Australian/Canadian hand index; OA, osteoarthritis.