Adverse events
| Statin naïve patients n=150 | Statin users n=47 | Statin naïve vs statin users p value | |||||
|---|---|---|---|---|---|---|---|
| Number | RA n=91 | AS n=40 | PsA n=19 | RA n=32 | AS n=10 | PsA n=5 | |
| Any adverse event | 10 (11.0) | 6 (15.0) | 6 (31.6) | 6 (18.8) | 0 (0.0) | 1 (20.0) | 0.83 |
| Gastrointestinal complaints | 4 (4.4) | 1 (2.5) | 1 (5.3) | 1 (3.1) | 0 (0.0) | 0 (0.0) | 0.48 |
| Nausea | 3 (3.3) | 1 (2.5) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0.23 |
| Myalgia | 3 (3.3) | 3 (7.5) | 1 (5.3) | 3 (9.4) | 0 (0.0) | 0 (0.0) | 0.75 |
| Rhabdomyolysis | – | – | – | – | – | – | – |
| Liver enzyme elevation >3×ULN | – | – | – | – | – | – | – |
| CK elevation >3×ULN | – | – | – | – | – | – | – |
| Others* | 3 (3.3) | 2 (5.0) | 4 (21.1) | 4 (12.5) | 0 (0.0) | 1 (20.0) | 0.38 |
Some patients experienced more than one side effect.
*Other side effects: Loss of memory (n=1), elevation in liver enzymes (n=3), oral dryness (n=1), near- angio-oedema (n=1), ankle oedema (n=3), hot flushes (n=1), fatigue (n=1), elevation of CK (n=1), headache (n=2), skin rash (n=1), vertigo (n=1), aphthous stomatitis (n=1).
AS, ankylosing spondylitis; CK, creatine kinase; PsA, psoriatic arthritis; RA, rheumatoid arthritis; ULN, upper limit normal.