Adverse events summary of patients with NOMID in a 24-month open-label study of canakinumab
| Type | n (%) | Type | n (%) |
|---|---|---|---|
| Ear disorders | Blood uric acid decrease | 2/2 (33.3) | |
| Ear pain | 2/2 (33.3) | C-reactive protein increase | 5/3 (50) |
| Gastrointestinal disorders | Basophil count increase | 2/2 (33.3) | |
| Gastrointestinal reflux | 2/1 (16.7) | Eosinophil count increase | 7/5 (83.3) |
| General disorders | Lymphocyte count increase | 2/2 (33.3) | |
| Pyrexia | 3/2 (33.3) | Monocyte count increase | 2/1 (33.3) |
| Infections | Neutrophil count increase | 3/2 (33.3) | |
| Ear infection | 1/1 (16.7) | RBC sedimentation rate | 2/2 (33.3) |
| Fungal infection | 1/1 (16.7) | WBC count increase | 2/2 (33.3) |
| Influenza | 1/1 (16.7) | CSF neutrophil count increase | 9/5 (83.3) |
| Localised infection | 1/1 (16.7) | CSF protein increase | 5/4 (66.7) |
| Sinusitis | 1/1 (16.7) | CSF WBC increase | 7/5 (83.3) |
| Staphylococcal infection | 1/1 (16.7) | Musculoskeletal disorders | |
| Subcutaneous abscess | 1/1 (16.7) | Arthralgia | 3/3 (50) |
| Injuries | Joint stiffness | 2/1 (16.7) | |
| Joint injury | 2/2 (33.3) | Nervous system disorders | |
| Laboratory parameters | Dizziness | 3/3 (50) | |
| Blood albumin decrease | 2/1 (16.7) | Headache | 8/4 (66.7) |
| Blood creatine phosphokinase decrease | 4/3 (50) | Respiratory disorders | |
| Blood creatinine decrease | 7/5 (83.3) | Oropharyngeal pain | 2/1 (16.7) |
Single episodes of the following also occurred: neutropenia, thrombocytopenia, conjunctivitis allergic, lacrimation increased, vision blurred, abdominal pain, nausea, condition aggravated, procedural pain, blood albumin increased, blood alkaline phosphatase increased, blood chloride increased, blood creatine phosphatase increased, blood glucose increased, blood triglycerides increased, haematocrit decreased, haemoglobin decreased, heart rate increased, high-density lipoprotein decreased, platelet count decreased, platelet count increased, red blood cell count increased, costochondritis, memory impairment, sinus headache, amenorrhoea, cough, nasal congestion, acne, eczema, pityriasis rosea, rash.
CSF, cerebral spinal fluid; NOMID, neonatal-onset multisystem inflammatory disease; RBC, red blood cells; WBC, white blood cells.