Example of inflammation/immune-related gene ontology (GO) terms for genes hypomethylated in osteoarthritic hip cluster 2
| GO term | Number of genes | Bonferroni p value |
|---|---|---|
| Immune system process | 198 | 1.28×10−19 |
| Immune response | 306 | 5.76×10−15 |
| Defence response | 128 | 2.1×10−11 |
| Regulation of immune response | 83 | 1.87×10−09 |
| Innate immune response | 87 | 3.78×10−09 |
| Activation of immune response | 45 | 1.04×10−05 |
| Immune system development | 62 | 1.18×10−05 |
| Lymphocyte activation | 32 | 3.41×10−04 |
| Regulation of leucocyte activation | 43 | 5.58×10−04 |
| Positive regulation of T cell activation | 27 | 5.91×10−04 |
| Regulation of defence response | 52 | 1.06×10−03 |
| Regulation of IL-1β production | 11 | 2.35×10−03 |
| Regulation of cytokine production | 48 | 3.14×10−03 |
| Positive regulation of leucocyte-mediated immunity | 15 | 1.01×10−02 |
| Regulation of T cell activation | 30 | 1.11×10−02 |
| Leucocyte differentiation | 21 | 1.13×10−02 |
| T cell co-stimulation | 14 | 1.26×10−02 |
| Response to interferon-gamma | 18 | 1.44×10−02 |
| Lymphocyte co-stimulation | 14 | 1.48×10−02 |
| Regulation of lymphocyte-mediated immunity | 16 | 2.69×10−02 |