Table 2

Association of inflammatory ultrasound features at baseline and progression of osteophytes and joint space narrowing in hand joints at risk for progression (max. 30 joints per patient) in 56 patients with hand osteoarthritis over 2.3 years of follow-up

ultrasound featureNumber of joints with/without progressionCrude OR (95% CI)Adjusted OR (95% CI)*Adjusted OR (95% CI)†
Osteophyte progression
PDS
 Grades 2+313/1314.8 (5.7 to 38.8)11.6 (4.1 to 32.6)5.7 (1.5 to 21.1)
 Grade 116/812.9 (1.7 to 5.0)3.4 (2.0 to 5.9)2.4 (1.3 to 4.7)
 Grade 091/1348111
Synovial thickening
 Grades 2+315/308.1 (4.3 to 15.1)6.1 (2.9 to 12.7)2.6 (1.02 to 6.5)
 Grade 121/566.0 (3.1 to 11.8)9.1 (4.3 to 18.9)5.5 (2.5 to 12.2)
 Grade 084/1356111
Effusion
 Grades 2+324/478.3 (4.7 to 14.8)7.0 (3.5 to 14.3)3.5 (1.7 to 7.4)
 Grade 122/1881.9 (1.09 to 3.3)1.5 (0.8 to 3.0)0.9 (0.4 to 1.9)
 Grade 074/1207111
Joint space narrowing progression
PDS
 Grades 2+38/1611.1 (4.1 to 29.8)6.3 (2.1 to 19.0)3.1 (1.01 to 9.2)
 Grade 114/903.0 (1.6 to 5.8)2.4 (1.3 to 4.3)2.0 (1.1 to 3.7)
 Grade 074/1378111
Synovial thickening
 Grades 2+312/279.5 (3.9 to 23.1)6.9 (2.8 to 17.3)3.4 (1.3 to 8.4)
 Grade 110/693.0 (1.4 to 6.4)2.3 (1.03 to 5.4)1.2 (0.5 to3.2)
 Grade 074/1388111
Effusion
 Grades 2+316/527.5 (3.6 to 15.6)4.3 (2.0 to 9.6)3.3 (1.5 to 7.6)
 Grade 125/1932.9 (1.6 to 5.4)1.9 (0.98 to 3.5)1.4 (0.7 to 2.9)
 Grade 055/1239111
  • *Model adjusted for age, gender, Body Mass Index (BMI), baseline joint space narrowing score and baseline osteophyte score.

  • †Model adjusted for age, gender, BMI, baseline osteophyte and baseline joint space narrowing score, and other baseline inflammatory features.

  • PDS, power Doppler signal.