Table 3

Point to consider 5: Summary of included studies describing the prognostic value of the imaging modalities

ReferenceNo. of subjectsDuration of follow-up (months)Radiological or clinical assessmentOutcome assessedCorrelation
Baseline CR predictive factors
Susic et al1208748Wrist involvementCHAQ-DISignificant correlation
Hip involvementSignificant correlation
JADI-ASignificant correlation
Ravelli et al2996min. 60CR wrist changes at: baseline in 1st year in 1st 5 years No. of joints with LOMBaseline: low r=0.16
1st year: low r=0.35
1st 5 years: moderate r=0.59
JADI-ABaseline: low r=0.21
1st year: moderate r=0.53
1st 5 years: moderate r=0.60
Steinbocker functional classBaseline: low r=0.21
1st year: moderate r=0.48
1st 5 years: moderate r=0.55
CR progression at 5 yearsBaseline: low r=0.38
1st year: moderate r=0.61
1st 5 years: high r=0.89
Pederzoli et al30130min. 60CR wrist a SH score > 1CR progression at 5 yearsSignificant predictor
OR 8.2
Magni-Manzoni et al289454Baseline Poznanski scoreCR progression in 1st yr
Baseline Poznanski scoreYearly CR progressionr=0.88
r=0.62, p<0.001
OR 14.32, p<0.0001
CR wrist progression in 1st yearFinal Poznanski scorer=0.58
r=0.59, p<0.0001
OR 6.49, p=0.0006
r=0.39, p=0.003
OR 8.42, p=0.002
Bertamino et al27148max. 132CR hip progression in 1st yearCHAQr=0.24, p=0.1
SJCr=0.03, p=0.86
TJCr=0.06, p=0.65
No. of joints with LOMr=0.46, p=0.0005
Steinbocker functional classr=0.50, p=0.005
JADI-Ar=0.45, p=0.01
Physician disability scorer=0.40, p=0.05
Parent disability scorer=0.53, p=0.007
Oen et al121136min. 60Early (<2 years) erosions/JSNCHAQNo correlation
Selvaag et al12219736Baseline swelling/osteopeniaCR erosive progressionOR 7.95, p<0.001
Less patients with CR progression had CHAQ of 0, p=0.045
Ringold et al3110429.9Early (<6 months) erosions/JSN vs normalTime with active disease
More time with active disease
Less chance of CRM, RR=0.34, p<0.001
RF +ve vs −veMore time with active disease
Oen et al5488Early (<2 years)
Late (1–20.8 years)
Late vs early JSNCHAQSignificant correlation
Explains 17.7% of variation in CHAQ
Joint painExplains 32.4% of variation in CHAQ
Habib et al12368ACPACR erosionsSignificant correlation
Arvidsson et al124103324Baseline/early TMJ involvementMicrognathia66.7% patients with micrognathia had baseline TMJ involvement; 33.3% had CR TMJ involvement within 2 years
Baseline MRI predictive factors
Malattia et al325812Baseline wrist synovial volumeMRI erosive progressionCorrelation r=0.42
All patients with high synovial volume had erosive progression
Baseline CRPCorrelation r=0.40
Gardner-Medwin et al1251012Baseline synovial hypertrophy in a clinically normal jointDisease extension from monoarthritis100% patients developed clinical arthritis in other joints
  • ACPA, anticyclic citrullinated peptide antibody; aSH, adapted Sharp van der Heijde score; CHAQ-DI, Childhood Health Assessment Questionnaire disability index; CR, conventional radiography; CRM, clinical remission on medication; CRP, C reactive protein; JADI-A, Juvenile Arthritis Damage Index for articular damage; JSN, joint space narrowing; LOM, limitation of movement; RF, rheumatoid factor; +ve, positive; −ve, negative; RR, relative risk; SJC, swollen joint count; TJC, tender joint count; TMJ, temporomandibular joint.