Baseline demographic, clinical and imaging characteristics of 100 anti-CCP positive patients with non-specific MSK symptoms
| Characteristic | No inflammatory arthritis at baseline (eligible; n=100) | |
|---|---|---|
| Age | Years* | 51.2 (11.9), 24–77 |
| Gender | Female | 72/100 (72%) |
| Shared epitope | One copy Two copies | 46/86 (53%) 17/86 (20%) |
| FDR with RA | Yes | 25/94 (27%) |
| Smoker | Ever | 70/99 (71%) |
| Alcohol consumer | No | 17/75 (23%) |
| BMI | Score* ≥25 | 29 (6.5), 18.3–44.7 54/76 (71%) |
| Anti-CCP | Level Low positive High positive | 246 (61, 825), 9–13 400 17/100 (17%) 83/100 (83%) |
| RF | Level† Low positive High positive | 21 (0, 103), 0–1000 15/100 (15%) 31/100 (31%) |
| Autoantibody status | Low positive RF and anti-CCP High positive RF or anti-CCP | 14/100 (14%) 86/100 (86%) |
| hsCRP | Level† ≥2 mg/dL | 2.9 (0.9, 10.5), 0.1–30 43/74 (58%) |
| Symptom duration | Months† ≥12 months | 22.7 (8.2, 42.4), 1.4–327.7 66/97 (68%) |
| Intermittent symptoms | Present | 20/97 (21%) |
| Tenderness of small joints | Count (0–34)†, range Present | 0.5 (0.0, 3.0), 0–18 50/100 (50%) |
| Symptoms in upper and lower extremities | Present | 37/100 (37%) |
| EMS | Minutes† ≥30 min | 10 (0, 38), 0–270 39/100 (39%) |
| Pain VAS | Millimetres† ≥50 mm | 24 (9–51), 0–100 25/91 (27%) |
| Power Doppler signal | Present | 33/100 (33%) |
Values presented are n/N (%) unless otherwise indicated.
*Mean (SD), range.
†Median (1st quartile, 3rd quartile), range.
Anti-CCP, anticyclic citrullinated peptide; BMI, body mass index; EMS, early morning stiffness; FDR, first degree relative; hsCRP, high sensitivity C reactive protein; MSK, musculoskeletal; RA, rheumatoid arthritis; RF, rheumatoid factor; VAS, visual analogue scale.