IRs and IRRs of OF: overall and subgroup analysis
| Subgroup | SSc IR | Control IR | IRR (95% CI) | p Value |
|---|---|---|---|---|
| All cohorts | ||||
| Overall fracture | 9.50 | 5.62 | 1.69 (1.30 to 2.18) | <0.001 |
| Vertebral fracture | 6.99 | 3.92 | 1.78 (1.30 to 2.39) | <0.001 |
| Hip fracture | 2.18 | 1.15 | 1.89 (1.05 to 3.22) | 0.026 |
| Radius fracture | 0.90 | 0.73 | 1.23 (0.47 to 2.72) | 0.592 |
| Female cohorts | ||||
| Overall fracture | ||||
| <50 years | 3.71 | 1.08 | 3.43 (1.65 to 6.75) | <0.001 |
| ≥50 years | 20.56 | 12.53 | 1.64 (1.21 to 2.19) | 0.001 |
| Total | 11.00 | 6.30 | 1.74 (1.32 to 2.27) | <0.001 |
| Vertebral fracture | ||||
| <50 years | 2.27 | 0.70 | 3.27 (1.24 to 7.74) | 0.011 |
| ≥50 years | 15.15 | 8.90 | 1.70 (1.19 to 2.39) | 0.003 |
| Total | 7.87 | 4.46 | 1.76 (1.27 to 2.41) | <0.001 |
| Hip fracture | ||||
| <50 years | 1.13 | 0 | – | <0.001 |
| ≥50 years | 4.72 | 2.54 | 1.86 (0.94 to 3.42) | 0.054 |
| Total | 2.70 | 1.17 | 2.30 (1.26 to 3.98) | 0.005 |
| Radius fracture | ||||
| <50 years | 0.57 | 0.38 | 1.48 (0.16 to 6.78) | 0.587 |
| ≥50 years | 1.80 | 1.44 | 1.25 (0.38 to 3.19) | 0.616 |
| Total | 1.11 | 0.87 | 1.27 (0.48 to 2.82) | 0.542 |
IR: the number of fractures per 1000 person-years.
IR, incidence rate; IRR, incidence rate ratio; OF, osteoporotic fracture; SSc, systemic sclerosis.