Table 2

Parameters related to inflammation and oxidative stress in APS, APS+SLE and SLE patients

Healthy donors (N=61)APS patients (N=41)p Value*APS+SLE patients (N=31)p Value* SLE patients (N=54)p Value*
Inflammatory parameters†
 Tissue factor (%)13.94±12.5322.13±17.460.02521.76±22.490.02218.34±13.970.035
 VEGF-A (pg/mL)350.42±240.96605.26±500.730.047488.62±335.660.035592.51±503.870.05
 IFN-α (pg/mL)126.33±207.8187.60±145.71n.s.84.03±133.01n.s.198.47±303.46n.s.
 IFN-γ (pg/mL)5.42±10.441.89±6.29n.s.0.27±0.75n.s.5.01±13.94n.s.
 IL-1ß (pg/mL)12.98±21.2613.45±18.82n.s.7.06±9.03n.s.33.09±45.51n.s.
 IL-2 (pg/mL)26.97±38.4436.81±82.31n.s.88.33±113.100.025155.07±213.390.002
 IL-6 (pg/mL)0.08±0.120.03±0.10n.s.4.00±7.230.0052.13±5.760.049
 IL-8 (pg/mL)7.51±22.2426.68±52.760.04527.51±44.130.00122.11±49.850.023
 IL-10 (pg/mL)23.41±65.1422.32±61.17n.s.0.31±0.81n.s.0.91±1.44n.s.
 IL-17 (pg/mL)5.30±19.8142.59±69.780.023107.44±220.890.004
 IL-23 (pg/mL)5.03±26.1519.43±36.600.04393.23±207.820.007
 MCP-1 (pg/mL)494.96±159.56610.41±269.950.0271222.19±720.470.001766.01±673.870.013
 MIP1-α (pg/mL)267.79±351.91453.86±502.260.047919.27±2777.75n.s.763.92±1756.36n.s.
 tPA (ng/mL)1.94±0.822.64±1.410.0153.79±1.610.0013.89±3.010.011
Oxidative status†
 TAC (plasma; mM Trolox equiv)150.98±71.85104.11±44.920.001126.42±36.98n.s.115.68±43.37n.s.
 Nitric oxide (plasma; µM)22.49±13.8115.39±8.170.00818.88±10.15n.s.12.16±6.890.001
 Nitrotyrosine (µM)19.29±20.4888.96±113.190.03234.70±25.750.01731.89±23.550.035
 Manganese-SOD (U/min/mL/µg prot)0.08±0.040.34±0.160.0210.18±0.220.0260.26±0.190.001
 Catalase (nmol/min/mL/µg protein)222.82±113.9286.22±51.530.012138.89±102.530.028181.56±137.61n.s.
 GPx (nmol/min/mL/µg protein)2.14±0.811.19±0.590.0031.37±0.770.0471.71±0.75n.s.
  • †Values are mean±SD.

  • *p<0.05 versus healthy donors.

  • APS, antiphospholipid syndrome; IFN, interferon; IL, interleukin; Manganese-SOD, manganese-superoxide dismutase; MCP-1, monocyte chemoattractant protein-1; SLE, systemic lupus erythematosus; TAC, total antioxidant capacity of plasma; VEGF, vascular endothelial growth factor.