Main clinical manifestations related to the APS that appeared during the 10-year follow-up (1999–2009) of the total cohort of 1000 patients
| Clinical manifestation* | 0 year† (n=1000) No. (%) | 0–5 year (n=1000) No. (%) | 5–10 year (n=796)‡ No (%) | 0–10 year (n=1000) No (%) |
|---|---|---|---|---|
| Thrombocytopenia (<100 000/µL) | 296 (29.6) | 37 (3.7) | 50 (6.3) | 87 (8.7) |
| Livedo reticularis | 241 (24.1) | 26 (2.6) | 55 (6.9) | 81 (8.1) |
| Stroke | 198 (19.8) | 24 (2.4) | 29 (3.6) | 53 (5.3) |
| Transient ischaemic attacks | 111 (11.1) | 23 (2.3) | 24 (3.0) | 47 (4.7) |
| Deep vein thrombosis | 389 (38.9) | 21 (2.1) | 22 (2.7) | 43 (4.3) |
| Pulmonary embolism | 141 (14.1) | 21 (2.1) | 14 (1.7) | 35 (3.5) |
| Epilepsy | 70 (7.0) | 17 (1.7) | 15 (1.9) | 32 (3.2) |
| Skin ulcers | 55 (5.5) | 17 (1.7) | 14 (1.7) | 31 (3.1) |
| Valve thickening/dysfunction | 116 (11.6) | 17 (1.7) | 29 (3.6) | 46 (4.6) |
| Vegetations | 27 (2.7) | 14 (1.4) | 7 (0.9) | 21 (2.1) |
| Myocardial infarction | 55 (5.5) | 9 (0.9) | 10 (1.2) | 19 (1.9) |
| Superficial thrombophlebitis | 117 (11.7) | 9 (0.9) | 8 (1.0) | 17 (1.7) |
| Autoimmune haemolytic anaemia | 97 (9.7) | 9 (0.9) | 31 (3.9) | 40 (4.0) |
| Obstetric manifestation§ | (n=1580) | (n=105) | (n=83) | (n=188) |
| Pre-eclampsia/eclampsia | 82 (5.2) | 8 (7.6) | 4 (4.8) | 12 (6.4) |
| Early pregnancy loss (<10 weeks) | 560 (35.4) | 18 (17.1) | 13 (15.7) | 31 (16.5) |
| Late pregnancy loss (≥10 weeks) | 267 (16.9) | 7 (6.7) | 2 (2.4) | 9 (4.8) |
| Live birth | 753 (47.6) | 80 (76.2) | 57 (68.7) | 137 (72.9) |
| Live birth with prematurity¶ | 80 (10.6) | 28 (35.0) | 38 (66.7) | 66 (48.2) |
| Live birth with intrauterine growth restriction¶ | 11 (1.5) | 11 (13.7) | 25 (43.8) | 36 (26.3) |
*Some patients had several associated presenting manifestations.
†Cumulative clinical manifestations at baseline. Previous period: median 6 years.
‡Number of patients that continued in the study in 2004.
§Obstetric manifestation related to number of pregnancy (n). Some women had more than one pregnancy.
¶Percentage related to number of live births.