Table 4

Linear regression analysis showing the relationships between DECT MSU crystal deposition, subcutaneous tophus count, serum urate and disease duration with structural joint damage on plain radiography: patient-level analysis (n=92)

Dependent variable	Predictors	B (SE)	Standardized B	p Value	Model
Number of joints with erosion	Number of joints with DECT MSU crystal deposition	0.33 (0.09)	0.39	0.001	R²=0.40, F=14.2, p<0.001
	Subcutaneous tophus count	0.09 (0.03)	0.33	0.002
	Serum urate concentration (mmol/L)	−0.24 (1.59)	−0.01	0.88
	Disease duration (years)	0.01 (0.02)	0.03	0.70
Total erosion score	Number of joints with DECT MSU crystal deposition	2.30 (0.42)	0.49	<0.001	R²=0.60, F=32.2, p<0.001
	Subcutaneous tophus count	0.58 (0.13)	0.37	<0.001
	Serum urate concentration (mmol/L)	1.39 (7.19)	0.02	0.85
	Disease duration (years)	0.10 (0.07)	0.10	0.16
Number of joints with joint space narrowing	Number of joints with DECT MSU crystal deposition	−0.01 (1.20)	−0.02	0.87	R²=0.29, F=9.0, p<0.001
	Subcutaneous tophus count	0.11 (0.02)	0.54	<0.001
	Serum urate concentration (mmol/L)	1.13 (1.20)	0.09	0.35
	Disease duration (years)	0.00 (0.01)	0.03	0.78
Total joint space narrowing score	Number of joints with DECT MSU crystal deposition	−0.04 (0.18)	−0.03	0.82	R²=0.23, F=6.6, p<0.001
	Subcutaneous tophus count	0.25 (0.06)	0.48	<0.001
	Serum urate concentration (mmol/L)	2.51 (3.18)	0.08	0.43
	Disease duration (years)	0.01 (0.03)	0.04	0.65
Number of joints with spur	Number of joints with DECT MSU crystal deposition	0.28 (0.06)	0.52	<0.001	R²=0.48, F=18.7, p<0.001
	Subcutaneous tophus count	0.04 (0.02)	0.23	0.02
	Serum urate concentration (mmol/L)	0.15 (0.95)	0.01	0.88
	Disease duration (years)	0.01 (0.01)	0.01	0.56
Number of joints with osteophyte	Number of joints with DECT MSU crystal deposition	0.12 (0.06)	0.25	0.06	R²=0.18, F=4.77, p=0.002
	Subcutaneous tophus count	0.03 (0.02)	0.19	0.12
	Serum urate concentration (mmol/L)	1.15 (1.05)	0.11	0.28
	Disease duration (years)	0.00 (0.01)	−0.01	0.96
Number of joints with periosteal new bone formation	Number of joints with DECT MSU crystal deposition	0.11 (0.05)	0.29	0.03	R²=0.14, F=3.5, p=0.01
	Subcutaneous tophus count	0.02 (0.02)	0.15	0.22
	Serum urate concentration (mmol/L)	−0.72 (0.82)	−0.10	0.39
	Disease duration (years)	0.00 (0.01)	0.01	0.89
Number of joints with sclerosis	Number of joints with DECT MSU crystal deposition	0.27 (0.09)	0.35	0.002	R²=0.37, F=12.7, p<0.001
	Subcutaneous tophus count	0.08 (0.03)	0.32	0.003
	Serum urate concentration (mmol/L)	−0.29 (1.5)	−0.02	0.85
	Disease duration (years)	0.02 (0.02)	0.11	0.19

DECT, dual-energy CT; MSU, monosodium urate.