Multivariable Cox proportional hazard analysis to evaluate factors (at time of TNFi discontinuation) related to loss of clinical benefit among all 717 patients
| MV model with CDAI | MV model with patient pain | MV model with mHAQ | |
|---|---|---|---|
| Age (<60 is reference) | 0.98 (0.84 to 1.16) | 1.01 (0.86 to 1.18) | 0.98 (0.83 to 1.15) |
| Female sex | 1.03 (0.85 to 1.25) | 1.05 (0.86 to 1.26) | 1.04 (0.86 to 1.26) |
| Caucasian (vs non-Caucasian) | 0.80 (0.65 to 0.99) | 0.78 (0.63 to 0.96) | 0.78 (0.64 to 0.97) |
| Ever smoker (current/former vs never) | 1.18 (1.00 to 1.40) | 1.18 (1.00 to 1.40) | 1.20 (1.02 to 1.42) |
| BMI (overweight/obese vs normal) | 1.24 (1.04 to 1.48) | 1.22 (1.02 to 1.46) | 1.23 (1.03 to 1.46) |
| CDAI at discontinuation (per unit change) | 1.28 (1.08 to 1.50) | – | – |
| Patient pain at disc | – | 1.24 (1.06 to 1.46) | – |
| mHAQ at disc | – | – | 1.21 (1.03 to 1.42) |
BMI, body mass index; CDAI, clinical disease activity score; mHAQ, modified Health Assessment Questionnaire.