Table 2

Summary of results of meta-analyses

OutcomesNo. studies (no. participants)Summary measure95% CIp Value
Serum hs-CRP levels and OA
 Absolute difference (mg/L) (OA vs control)14 (5483)MD=1.190.64 to 1.73<0.001*
 Odds ratio (progressive vs non-progressive OA)4 (10 619)OR=0.990.81 to 1.210.93
Correlation between hs-CRP levels and OA phenotypes
 Kellgren–Lawrence grade2 (95)r=0.13−0.08 to 0.350.22
 Joint space width2 (205)r=-0.10−0.29 to 0.100.33
 Pain5 (1233)r=0.140.09 to 0.20<0.001*
 Physical function reduction2 (244)r=0.250.13 to 0.39<0.001*
  • *Indicates statistical significance.

  • hs-CRP: high sensitivity c reactive protein; MD: mean difference; OA: osteoarthritis; r: coefficient correlation.