Outcomes | No. studies (no. participants) | Summary measure | 95% CI | p Value |
---|---|---|---|---|
Serum hs-CRP levels and OA | ||||
Absolute difference (mg/L) (OA vs control) | 14 (5483) | MD=1.19 | 0.64 to 1.73 | <0.001* |
Odds ratio (progressive vs non-progressive OA) | 4 (10 619) | OR=0.99 | 0.81 to 1.21 | 0.93 |
Correlation between hs-CRP levels and OA phenotypes | ||||
Kellgren–Lawrence grade | 2 (95) | r=0.13 | −0.08 to 0.35 | 0.22 |
Joint space width | 2 (205) | r=-0.10 | −0.29 to 0.10 | 0.33 |
Pain | 5 (1233) | r=0.14 | 0.09 to 0.20 | <0.001* |
Physical function reduction | 2 (244) | r=0.25 | 0.13 to 0.39 | <0.001* |
*Indicates statistical significance.
hs-CRP: high sensitivity c reactive protein; MD: mean difference; OA: osteoarthritis; r: coefficient correlation.