Table 4

Cartilage volume loss (%) over time in patients with BML at baseline in medial subregions

	SrRan 1 g/day		SrRan 2 g/day		Placebo		p Value*	Placebo versus SrRan 1 g/day p Value**	Placebo versus SrRan 2 g/day p Value**	SrRan 1 g/day versus SrRan 2 g/day p Value**
	n	Mean±SD	n	Mean±SD	n	Mean±SD	p Value*	Placebo versus SrRan 1 g/day p Value**	Placebo versus SrRan 2 g/day p Value**	SrRan 1 g/day versus SrRan 2 g/day p Value**
Medial compartment (months)
12	31	−4.85±4.03	23	−3.80±3.26	30	−4.73±3.82	0.779
24	31	−7.29±2.98	23	−5.58±5.60	30	−6.66±5.35	0.310
36	31	−9.29±3.19	23	−7.84±5.67	30	−10.12±4.27	0.078	>0.999	0.180	0.116
Medial femur (months)
12	24	−5.00±5.08	18	−5.71±3.85	24	−4.63±5.01	0.599
24	24	−7.39±4.07	18	−6.50±5.71	24	−7.74±5.16	0.549
36	24	−8.96±3.79	18	−10.49±5.89	24	−10.22±3.69	0.352
Medial central condyle (months)
12	12	−5.36±12.71	10	−5.82±5.68	9	−5.03±5.65	0.973
24	12	−11.34±5.05	10	−6.63±7.05	9	−12.02±8.79	0.330
36	12	−12.88±6.82	10	−11.45±4.72	9	−17.54±11.19	0.129
Medial plateau (months)
12	15	−3.50±6.36	9	0.29±6.84	10	−4.52±6.31	0.174
24	15	−4.94±4.56	9	−1.85±6.68	10	−6.53±9.79	0.364
36	15	−7.87±5.07	9	−0.55±3.30	10	−13.80±13.51	0.001	0.763	0.023	0.002

p Values were assessed using the *Kruskal–Wallis test and the **Mann–Whitney test with Bonferroni adjustment. BML, bone marrow lesion; n, number of participants; SrRan, strontium ranelate. p Values in bold are significantly different.