Table 3

Adjusted HRs of death by categories of mean disease activity of the patients at follow-up

PYRSAdjusted HR (95%CI)p Value
DAS28 3.2–4.188751.29 (0.85 to 1.93)0.21
DAS28>4.1–5.187731.42 (0.96 to 2.10)0.073
DAS28>5.169992.43 (1.64 to 3.61)0.0001
  • The risk window approach was used to calculate the adjusted HRs. Adjustments were made for age, sex, smoking, comorbid conditions (chronic lung disease, diabetes, coronary heart disease, chronic renal disease, prior malignancy and osteoporosis) and as time-dependent risk factors treatment with glucocorticoids, treatment with methotrexate, other synthetic disease modifying antirheumatic drugs, TNFα inhibitors, rituximab, or other biologics. Updated FFbH scores were not included in the risk set. (PYRS: patient-years).