Table 1

mITT baseline demographics, clinical and imaging characteristics

	SrRan 1 g/day (n=113)	SrRan 2 g/day (n=105)	Placebo (n=112)	p Value*	Placebo versus SrRan 1 g/day p Value**	Placebo versus SrRan 2 g/day p Value**	SrRan 1 g/day versus SrRan 2 g/day p Value**
Demographics and clinical
Age, years	60±7	63±7	62±8	0.062	0.307	>0.999	0.059
Women, n (%)	70 (62%)	70 (67%)	76 (68%)	0.616†
BMI, kg/m²	30±5	30±5	30±5	0.684
WOMAC
Pain (0–100)	42.0±20.4	44.5±20.0	38.5±21.4	0.068	0.438	0.079	0.927
Function (0–100)	42.5±20.8	42.3±23.1	39.3±22.4	0.476
Stiffness (0–100)	47.1±23.4	48.9±24.8	43.0±23.4	0.182
Total (0–300)	132.9±59.0	135.1±62.1	122.1±62.9	0.284
Pain VAS (0–100 mm)	51.1±21.5	54.9±23.2	49.8 ±23.9	0.211
Imaging
Kellgren–Lawrence, n (%)
Grade 1	–	–	–
Grade 2	77 (68%)	68 (65%)	75 (67%)	0.866†
Grade 3	36 (32%)	37 (35%)	37 (33%)
Joint space width (mm)	3.49±0.85	3.54 ±0.82	3.50 ±0.74	0.820
MRI (mm³)
Meniscal extrusion (yes)	19 (17%)	15 (14%)	26 (23%)	0.210†
Presence of BML (yes)	44 (39%)	35 (33%)	46 (41%)	0.482†
Global knee	11 439±3012	11 708±3313	11 076±2827	0.400
Femur	7883 ±2141	8138 ±2276	7686 ±2003	0.374
Plateau	3556 ±966	3570 ±1145	3390 ±895	0.430
Medial compartment
Femur	3833 ±1009	3965 ±1075	3730 ±955	0.286
Plateau	1611 ±448	1624 ±523	1540 ±432	0.509
Lateral compartment
Femur	4050 ±1213	4173 ±1274	3956 ±1118	0.555
Plateau	1945 ±580	1946 ±675	1849 ±534	0.524

The results are shown as mean±SD unless otherwise indicated.
p Values were assessed using the *Kruskal–Wallis test, the †χ² test and the **Mann–Whitney test with Bonferroni adjustment.
BMI, body mass index; BML, bone marrow lesion; mITT, modified intention-to-treat; n, number of participants; SrRan, strontium ranelate; VAS, Visual Analogue Scale (0 mm=no pain, 100 mm=most severe pain); WOMAC, Western Ontario and McMaster Universities Osteoarthritis Index (each subscale, 100=worst score; total scale, 300=worst score).