Psychometric properties of primary Sjogren's syndrome activity and patient scores
| Construct validity | Responsiveness | ||||
|---|---|---|---|---|---|
| Spearman r correlation coefficient with PhGA or PGA | Reliability ICC (95% IC) | SRM for improved patients | SRM for stable patients | SRM for worsened patients | |
| Physician outcome measures | N=47 | N=62 | N=198 | N=50 | |
| ESSDAI | 0.59 | 0.96 (0.89;0.98) | −0.72 (−0.97; −0.53) | −0.17 (−0.30;−0.02) | +0.26 (0.02;0.57) |
| SSDAI | 0.34 | 0.83 (0.56;0.94) | −0.82 (−1.06;−0.62) P=0.23 | −0.26 (−0.41;−0.11) P=0.29 | +0.43 (0.15;0.83) P=0.22 |
| SCAI | 0.32 | 0.95 (0.85;0.98) | −0.69 (−0.95;−0.47) P=0.18 | −0.22 (−0.39;−0.05) P=0.34 | +0.37 (0.07;0.75) P=0.45 |
| Patient-centred measures | N=62 | N=95 | N=151 | N=72 | |
| ESSPRI | 0.70 | 0.94 (0.89;0.97) | −0.37 (−0.60;−0.17) | +0.08 (−0.08;+0.24) | +0.37 (0.15;0.16) |
| SSI | 0.55 | 0.86 (0.77;0.91) | −0.04 (−0.26;+0.15) P=0.006 | +0.07 (−0.10;+0.23) P=0.43 | +0.34 (0.03;0.48) P=0.26 |
| PROFAD | 0.58 | 0.92 (0.87;0.96) | −0.16 (−0.35;+0.06) P=0.049 | +0.15 (−0.01;+0.31) P=0.19 | +0.32 (0.08;0.58) P=0.21 |
ESSDAI, EULAR Sjögren's Syndrome Disease Activity Index; EULAR, European League Against Rheumatism; ICC, intraclass correlation coefficient; PGA, patient global assessment; PROFAD, Profile of Fatigue and Discomfort; SCAI, Sjögren's Systemic Clinical Activity Index; SRM, standardised response mean; SSI, Sicca Symptoms Inventory.