−Analgesic/NSAIDs | +Analgesic/NSAIDs | |||||
---|---|---|---|---|---|---|
+Glu/CS (n=90) | −Glu/CS (n=210) | p Value† | +Glu/CS (n=113) | −Glu/CS (n=187) | p Value† | |
12 Months | ||||||
Loss of JSW (mm) | 0.02 (0.61)‡ | −0.12 (0.47)§ | 0.25 | −0.16 (0.64)¶ | −0.14 (0.57)** | 0.30 |
MRI change (%) | (n=85) | (n=195) | (n=108) | (n=175) | ||
Global knee | −1.2 (3.4) | −1.6 (3.1) | 0.44 | −1.8 (3.6) | −2.2 (3.7) | 0.60 |
Condyle | −1.2 (3.4) | −1.3 (3.2) | 0.86 | −1.9 (4.3) | −1.9 (3.9) | 0.57 |
Plateau | −1.2 (4.8) | −2.1 (4.6) | 0.28 | −1.5 (4.6) | −2.8 (5.1) | 0.05 |
Central plateau | −1.2 (4.9) | −2.2 (5.1) | 0.14 | −1.5 (5.0) | −2.9 (5.2) | 0.09 |
Peripheral plateau | −1.3 (5.3) | −1.9 (4.8) | 0.47 | −1.5 (4.9) | −2.8 (5.5) | 0.07 |
Medial compartment | −1.3 (4.2) | −1.9 (3.6) | 0.43 | −2.1 (5.9) | −2.4 (4.7) | 0.66 |
Condyle | −1.1 (4.8) | −1.5 (4.0) | 0.61 | −2.1 (7.3) | −2.2 (5.1) | 0.93 |
Plateau | −1.5 (6.2) | −2.5 (6.8) | 0.32 | −2.2 (7.1) | −2.7 (7.3) | 0.48 |
Central plateau | −1.2 (6.3) | −2.5 (7.2) | 0.19 | −2.5 (7.5) | −2.6 (7.9) | 0.72 |
Peripheral plateau | −1.7 (6.6) | −2.4 (7.5) | 0.58 | −2.0 (7.6) | −2.6 (7.5) | 0.52 |
Lateral compartment | −1.2 (3.9) | −1.5 (3.8) | 0.65 | −1.6 (4.0) | −2.3 (4.1) | 0.17 |
Condyle | −1.2 (3.7) | −1.2 (3.9) | 0.83 | −1.8 (4.6) | −1.7 (4.1) | 0.67 |
Plateau | −1.3 (6.6) | −1.8 (6.0) | 0.12 | −0.9 (5.4) | −3.2 (6.1) | 0.005 |
Central plateau | −1.4 (7.2) | −2.0 (6.0) | 0.13 | −0.8 (6.1) | −3.2 (6.5) | 0.009 |
Peripheral plateau | −1.3 (6.8) | −1.6 (7.6) | 0.33 | −0.9 (6.0) | −3.1 (6.8) | 0.007 |
24 Months | ||||||
Loss of JSW (mm) | −0.05 (0.85)†† | −0.16 (0.65)‡‡ | 0.65 | −0.16 (0.72)§§ | −0.20 (0.66)¶¶ | 0.99 |
MRI change (%) | ||||||
Global knee | −2.4 (4.0) | −2.7 (3.8) | 0.52 | −3.3 (3.8) | −3.8 (4.5) | 0.57 |
Condyle | −1.9 (4.4) | −2.1 (3.7) | 0.52 | −3.2 (3.7) | −3.0 (4.5) | 0.62 |
Plateau | −3.2 (5.1) | −3.8 (5.5) | 0.47 | −3.7 (5.6) | −5.3 (6.5) | 0.10 |
Central plateau | −3.4 (5.7) | −3.9 (6.1) | 0.36 | −3.7 (5.6) | −5.4 (6.8) | 0.05 |
Peripheral plateau | −3.1 (5.3) | −3.6 (5.8) | 0.48 | −3.7 (6.1) | −5.2 (7.0) | 0.17 |
Medial compartment | −2.3 (4.7) | −3.0 (4.6) | 0.23 | −3.8 (5.4) | −4.0 (6.1) | 0.92 |
Condyle | −2.0 (5.8) | −2.4 (4.7) | 0.46 | −3.5 (5.0) | −3.3 (6.1) | 0.48 |
Plateau | −2.3 (6.7) | −4.2 (8.5) | 0.08 | −4.4 (9.0) | −5.9 (9.4) | 0.39 |
Central plateau | −2.0 (7.5) | −4.4 (8.6) | 0.007 | −3.9 (8.9) | −5.8 (10.4) | 0.30 |
Peripheral plateau | −2.6 (6.9) | −4.0 (9.6) | 0.37 | −4.8 (10.1) | −6.0 (9.8) | 0.46 |
Lateral compartment | −2.8 (4.8) | −2.5 (4.5) | 0.76 | −3.2 (4.3) | −3.9 (5.0) | 0.25 |
Condyle | −2.1 (5.0) | −1.9 (4.3) | 0.96 | −3.0 (4.6) | −3.1 (4.8) | 0.92 |
Plateau | −4.1 (6.8) | −3.2 (6.4) | 0.61 | −3.9 (7.0) | −5.3 (7.6) | 0.08 |
Central plateau | −4.5 (8.0) | −3.5 (7.0) | 0.59 | −4.0 (7.8) | −5.4 (8.4) | 0.11 |
Peripheral plateau | −3.7 (6.9) | −2.8 (7.5) | 0.73 | −3.8 (7.4) | −5.1 (8.1) | 0.14 |
*Results are shown as mean (±SD), unless otherwise mentioned.
†p Values were assessed using the Mann–Whitney test.
‡n=86.
§n=201.
¶n=107.
**n=172.
††n=88.
‡‡n=209.
§§n=106.
¶¶n=179.
BMI, Body Mass Index; JSW, joint space width; KOOS, Knee injury and Osteoarthritis Outcome Score (0=worst, 100=best score); n, number of participants; WOMAC, Western Ontario and McMaster Universities Osteoarthritis Index (0=best, 96=worst score).