Table 2

Results of intraclass coefficient (ICC) and measure of agreement (α score) for both sets of 11 biopsies* scored in the 11×11 scoring exercises, with 95% CIs†

DomainQuadricepsBiceps
ICCα ScoreICCα Score
Inflammatory domain0.81 (0.61 to 0.93)0.38 (0.19 to 0.74)0.80 (0.62 to 0.93)0.34 (0.16 to 0.68)
CD3+ endomysial infiltration0.72 (0.53 to 0.89)0.15 (0.0 to 0.39)0.74 (0.56 to 0.90)0.26 (0.08 to 0.54)
CD3+ perimysial infiltration0.61 (0.39 to 0.83)0.31 (0.05 to 0.67)0.75 (0.57 to 0.91)0.20 (0 to 0.44)
CD3+ perivascular infiltration0.58 (0.37 to 0.82)0.41 (0.14 to 0.84)0.58 (0.37 to 0.82)0.44 (0.17 to 0.90)
CD68+ endomysial infiltration0.66 (0.45 to 0.86)0.40 (0.17 to 0.82)0.62 (0.41 to 0.84)0.22 (0.0 to 0.53)
CD68+ perimysial infiltration0.48 (0.27 to 0.76)0.59 (0.24 to 1.2)0.79 (0.63 to 0.93)0.18 (0.0 to 0.40)
CD68+ perivascular infiltration0.40 (0.20 to 0.70)0.83 (0.37 to 1.65)0.33 (0.15 to 0.63)0.97 (0.43 to 0.93)
Vascular domain0.48 (0.27 to 0.76)0.57 (0.23 to 1.2)0.49 (0.28 to 0.76)0.54 (0.21 to 1.10)
Capillary dropout0.39 (0.20 to 0.68)0.73 (0.29 to 1.47)0.26 (0.11 to 0.55)0.95 (0.34 to 2.0)
Arterial abnormality0.40 (0.21 to 0.70)0.56 (0.18 to 1.18)0.42 (0.23 to 0.71)0.52 (0.15 to 1.09)
Infarction0 (0 to 0.16)00.42 (0.22 to 0.71)0.34 (0 to 0.80)
Muscle fibre domain0.80 (0.63 to 0.93)0.25 (0.10 to 0.52)0.86 (0.71 to 0.95)0.26 (0.12 to 0.52)
MHC class I overexpression0.31 (0.14 to 0.62)0.28 (0.0 to 0.82)0 (0 to 0.14)0
Perifascicular atrophy0.63 (0.43 to 0.85)0.28 (0 to 0.61)0.76 (0.58 to 0.9100.29 (0.11 to 0.59)
Neonatal myosin0.83 (0.68 to 0.94)0 (0 to 0.20)0.88 (0.76 to 0.96)0.06 (0 to 0.20)
Fibre atrophy: non-perifascicular0.28 (0.13 to 0.59)0.83 (0.29 to 1.72)0.32 (0.15 to 0.62)0.76 (0.26 to 1.56)
Regeneration/degeneration/necrosis: perifascicular0.58 (0.36 to 0.82)0.39 (0.12 to 0.81)0.84 (0.70 to 0.94)0.18 (0.05 to 0.30)
Regeneration/degeneration/necrosis: non-perifascicular0.51 (0.30 to 0.78)0.38 (0.05 to 0.81)0.60 (0.38 to 0.83)0.50 (0.22 to 1.0)
Internal myonuclei0.63 (0.42 to 0.85)0.33 (0.09 to 0.69)0.32 (0.15 to 0.63)0.63 (0.16 to 1.34)
Connective tissue domain0.34 (0.16 to 0.64)0.74 (0.27 to 1.52)0.41 (0.21 to 0.70)0.62 (0.23 to 1.28)
Any endomysial fibrosis0.35 (0.17 to 0.65)0.66 (0.22 to 1.38)0.32 (0.15, 0.63)0.60 (0.11 to 1.39)
Any perimysial fibrosis0.19 (0.07 to 0.47)1.03 (0.26 to 2.17)0.36 (0.18 to 0.66)0.70 (0.26 to 1.44)
Histopathologists’ Visual Analogue Score for severity0.77 (0.60 to 0.91)0.20 (0.03 to 0.44)0.87 (0.74 to 0.96)0.19 (0.08 to 0.40)
  • *All 22 cases used to generate these data were new cases, distinct from the previous study.4

  • †ICC>0.6 indicates high reliability, α score <0.4 indicates high agreement.

  • ‡Items shown in bold reached good or good*, as detailed in text.